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10.1038/bjc.2017.163 http://scihub22266oqcxt.onion/10.1038/bjc.2017.163 C5520513!5520513!28632728     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 2017 ; 117 (2): 227-32 Nephropedia Template TP {{tp|p=28632728|t=2017. Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer |pdf=|usr=}}{{28632728}} gab.com Text Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28632728 #FOAvip Background:: We previously reported that GTA-446 may be a useful biomarker for early detection of colorectal cancer. In the present study, we confirmed the clinical feasibility of GTA-446 as a screening tool for colorectal cancer with a novel measurement system developed for clinical use. We also improved sensitivity by analysing GTA-446 levels according to gender. Methods:: Serum samples were collected from 225 colorectal cancer patients and 916 healthy volunteers to measure GTA-446 levels by flow injection analysis?mass spectrometry. Results:: GTA-446 levels were downregulated in colorectal cancer patients compared with the healthy volunteers, and in females compared with the males in both groups. Receiver operating characteristic curve analysis revealed an optimal cut-off of 2.72??mol?l?1 in males and 1.87??mol?l?1 in females, with a large area under the curve of 0.89?0.93. The sensitivity and specificity were 90.4% and 84.9% for males, 85.2% and 80.5% for females, and 83.3% and 84.8% for all subjects, respectively. Conclusions:: GTA-446 is a clinically relevant biomarker for colorectal cancer with high sensitivity when analysed by gender. Thus, GTA-446 is a promising tool for primary colorectal cancer screening to identify populations at a higher risk of colorectal cancer, with an emphasis on early detection. Twit Text FOAVip Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28632728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28632728 #FOAvip English Wikipedia <ref>{{Cite pmid|28632728}}</ref> Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer #MMPMID28632728 Hata T; Takemasa I; Takahashi H; Haraguchi N; Nishimura J; Hata T; Mizushima T; Doki Y; Mori M Br J Cancer 2017[Jul]; 117 (2): 227-32 PMID28632728show ga Background:: We previously reported that GTA-446 may be a useful biomarker for early detection of colorectal cancer. In the present study, we confirmed the clinical feasibility of GTA-446 as a screening tool for colorectal cancer with a novel measurement system developed for clinical use. We also improved sensitivity by analysing GTA-446 levels according to gender. Methods:: Serum samples were collected from 225 colorectal cancer patients and 916 healthy volunteers to measure GTA-446 levels by flow injection analysis?mass spectrometry. Results:: GTA-446 levels were downregulated in colorectal cancer patients compared with the healthy volunteers, and in females compared with the males in both groups. Receiver operating characteristic curve analysis revealed an optimal cut-off of 2.72??mol?l?1 in males and 1.87??mol?l?1 in females, with a large area under the curve of 0.89?0.93. The sensitivity and specificity were 90.4% and 84.9% for males, 85.2% and 80.5% for females, and 83.3% and 84.8% for all subjects, respectively. Conclusions:: GTA-446 is a clinically relevant biomarker for colorectal cancer with high sensitivity when analysed by gender. Thus, GTA-446 is a promising tool for primary colorectal cancer screening to identify populations at a higher risk of colorectal cancer, with an emphasis on early detection. äDownregulation of serum metabolite GTA-446 as a novel potential marker(epmc).pdf DeepDyve Pubget Overpricing