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Implementation of longevity-promoting supplements and medications in public
health practice: achievements, challenges and future perspectives
#MMPMID28728596
Vaiserman A
; Lushchak O
J Transl Med
2017[Jul]; 15
(1
): 160
PMID28728596
show ga
BACKGROUND: Most modern societies undergo rapid population aging. The rise in
life expectancy, nevertheless, is not accompanied, to date, by the same increment
of healthspan. Efforts to increase healthspan by means of supplements and
pharmaceuticals targeting aging-related pathologies are presently in spotlight of
a new branch in geriatric medicine, geroscience, postulating that aging could be
manipulated in such a way that will in parallel allow delay the onset of all
age-associated chronic disorders. DISCUSSION: Currently, the concept of the
"longevity dividend" has been developed pointed out that the extension of
healthspan by slowing the rate of aging is the most efficient way to combat
various aging-related chronic illnesses and disabling conditions than combating
them one by one, what is the present-day approach in a generally accepted
disease-based paradigm. The further elaboration of pharmaceuticals specifically
targeted at age-associated disorders (commonly referred to as 'anti-aging drugs')
is currently one of the most extensively developed fields in modern
biogerontology. Some classes of chemically synthesized compounds and
nutraceuticals such as calorie restriction mimetics, autophagy inductors,
senolytics and others have been identified as having potential for anti-aging
intervention through their possible effects on basic processes underlying aging.
In modern pharmaceutical industry, development of new classes of anti-aging
medicines is apparently one of the most hopeful directions since potential target
group may include each adult individual. Implementation of the geroscience-based
approaches into healthcare policy and practice would increase the ratio of
healthy to unhealthy population due to delaying the onset of age-associated
chronic pathologies. That might result in decreasing the biological age and
increasing the age of disability, thus increasing the age of retirement and
enhancing income without raising taxes. Economic, social and ethical aspects of
applying the healthspan- and lifespan-promoting interventions, however, have to
be comprehensively debated prior to their implementation in public health
practice.
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