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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Occup+Environ+Med
2017 ; 74
(3
): 211-217
Nephropedia Template TP
Occup Environ Med
2017[Mar]; 74
(3
): 211-217
PMID27821675
show ga
OBJECTIVE: To understand why 2 studies relating crystalline silica exposure to
lung-cancer mortality in Vermont granite workers yielded conflicting results.
METHODS: Data used in the 2 studies were linked to identify discrepancies.
Mortality data and employment histories from the earlier study were revised based
on data obtained in the later study. SMR were computed and Poisson regressions
corresponding to those in the earlier study were performed using the original and
revised data. Analyses were repeated with the addition of workers omitted from
the earlier study. RESULTS: After correction of incomplete mortality and
employment information in the original data, the overall SMR for the cohort in
the earlier study increased from 1.17 (95% CI 1.03 to 1.36) to 1.39 (95% CI 1.22
to 1.59), and was similar to the SMR of 1.37 observed in the later study (95% CI
1.23 to 1.52). The exposure-response relationship was attenuated, particularly
when person-years in all exposure categories were included in the analysis.
Inclusion of additional workers had a smaller impact on the SMRs but further
attenuated the exposure-response relationship. CONCLUSIONS: Differing results
from the 2 studies are partly attributable to incomplete vital status and work
history information used in the earlier study, as well as differences in cohort
inclusion criteria. However, differences in length of follow-up and other factors
likely play a larger role.