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10.1038/cdd.2017.46 http://scihub22266oqcxt.onion/10.1038/cdd.2017.46 C5520167!5520167 !28362430     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28362430 &cmd=llinks): Failed to open stream: HTTP request failed! 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CYLD, A20 and OTULIN deubiquitinases in NF-?B signaling and cell death: so similar, yet so different |pdf=|usr=}}{{28362430 }} gab.com Text CYLD, A20 and OTULIN deubiquitinases in NF- B signaling and cell death: so similar, yet so different JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28362430 #FOAvip Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular functions such as protein degradation, DNA repair and cell signaling. As deregulation of these processes can result in pathological conditions such as inflammatory diseases, neurodegeneration or cancer, tight regulation of the ubiquitin system is of tremendous importance. Ubiquitination by E3 ubiquitin ligases can be counteracted by the activity of several deubiquitinating enzymes (DUBs). CYLD, A20 and OTULIN have been implicated as key DUBs in the negative regulation of NF-?B transcription factor-mediated gene expression upon stimulation of cytokine receptors, antigen receptors and pattern recognition receptors, by removing distinct types of polyubiquitin chains from specific NF-?B signaling proteins. In addition, they control TNF-induced cell death signaling leading to apoptosis and necroptosis via similar mechanisms. In the case of A20, also catalytic-independent mechanisms of action have been demonstrated to have an important role. CYLD, A20 and OTULIN have largely overlapping substrates, suggesting at least partially redundant functions. However, mice deficient in one of the three DUBs show significant phenotypic differences, indicating also non-redundant functions. Here we discuss the activity and polyubiquitin chain-type specificity of CYLD, A20 and OTULIN, their specific role in NF-?B signaling and cell death, the molecular mechanisms that regulate their activity, their role in immune homeostasis and the association of defects in their activity with inflammation, autoimmunity and cancer. Twit Text FOAVip CYLD, A20 and OTULIN deubiquitinases in NF- B signaling and cell death: so similar, yet so different ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28362430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28362430 #FOAvip English Wikipedia <ref>{{Cite pmid|28362430 }}</ref> CYLD, A20 and OTULIN deubiquitinases in NF-?B signaling and cell death: so similar, yet so different #MMPMID28362430 Lork M ; Verhelst K ; Beyaert R Cell Death Differ 2017[Jul]; 24 (7 ): 1172-1183 PMID28362430 show ga Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular functions such as protein degradation, DNA repair and cell signaling. As deregulation of these processes can result in pathological conditions such as inflammatory diseases, neurodegeneration or cancer, tight regulation of the ubiquitin system is of tremendous importance. Ubiquitination by E3 ubiquitin ligases can be counteracted by the activity of several deubiquitinating enzymes (DUBs). CYLD, A20 and OTULIN have been implicated as key DUBs in the negative regulation of NF-?B transcription factor-mediated gene expression upon stimulation of cytokine receptors, antigen receptors and pattern recognition receptors, by removing distinct types of polyubiquitin chains from specific NF-?B signaling proteins. In addition, they control TNF-induced cell death signaling leading to apoptosis and necroptosis via similar mechanisms. In the case of A20, also catalytic-independent mechanisms of action have been demonstrated to have an important role. CYLD, A20 and OTULIN have largely overlapping substrates, suggesting at least partially redundant functions. However, mice deficient in one of the three DUBs show significant phenotypic differences, indicating also non-redundant functions. Here we discuss the activity and polyubiquitin chain-type specificity of CYLD, A20 and OTULIN, their specific role in NF-?B signaling and cell death, the molecular mechanisms that regulate their activity, their role in immune homeostasis and the association of defects in their activity with inflammation, autoimmunity and cancer. |*Signal Transduction [MESH] |Animals [MESH] |Cell Death [MESH] |Deubiquitinating Enzymes/*metabolism [MESH] |Humans [MESH] |Models, Biological [MESH] |NF-kappa B/*metabolism [MESH]CYLD, A20 and OTULIN deubiquitinases in NF-?B signaling and cell death(epmc).pdf DeepDyve Pubget Overpricing