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10.1038/bjc.2017.108 http://scihub22266oqcxt.onion/10.1038/bjc.2017.108 C5520088!5520088 !28427085     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28427085 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer |pdf=|usr=}}{{28427085 }} gab.com Text Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28427085 #FOAvip BACKGROUND: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer. METHODS: The tumour microenvironment was examined using measures of the inflammatory infiltrate (Klintrup-Makinen (KM) grade and Immunoscore), tumour stroma percentage (TSP) and tumour budding. The systemic inflammatory environment was examined using modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR). A 5-year CSS was examined. RESULTS: A total of 331 patients were included. Increasing T stage was associated with colonic primary, N stage, poor differentiation, margin involvement and venous invasion (P<0.05). T stage was significantly associated with KM grade (P=0.001), Immunoscore (P=0.016), TSP (P=0.006), tumour budding (P<0.001), and elevated mGPS and NLR (both P<0.05). In patients with T3 cancer, N stage stratified survival from 88 to 64%, whereas Immunoscore and budding stratified survival from 100 to 70% and from 91 to 56%, respectively. The Glasgow Microenvironment Score, a score based on KM grade and TSP, stratified survival from 93 to 58%. CONCLUSIONS: Although associated with increasing T stage, local and systemic tumour environment characteristics, and in particular Immunoscore, budding, TSP and mGPS, are stage-independent determinants of survival and may be utilised in the staging of patients with primary operable colorectal cancer. Twit Text FOAVip Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28427085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28427085 #FOAvip English Wikipedia <ref>{{Cite pmid|28427085 }}</ref> Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer #MMPMID28427085 Park JH ; van Wyk H ; Roxburgh CSD ; Horgan PG ; Edwards J ; McMillan DC Br J Cancer 2017[May]; 116 (11 ): 1444-1450 PMID28427085 show ga BACKGROUND: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer. METHODS: The tumour microenvironment was examined using measures of the inflammatory infiltrate (Klintrup-Makinen (KM) grade and Immunoscore), tumour stroma percentage (TSP) and tumour budding. The systemic inflammatory environment was examined using modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR). A 5-year CSS was examined. RESULTS: A total of 331 patients were included. Increasing T stage was associated with colonic primary, N stage, poor differentiation, margin involvement and venous invasion (P<0.05). T stage was significantly associated with KM grade (P=0.001), Immunoscore (P=0.016), TSP (P=0.006), tumour budding (P<0.001), and elevated mGPS and NLR (both P<0.05). In patients with T3 cancer, N stage stratified survival from 88 to 64%, whereas Immunoscore and budding stratified survival from 100 to 70% and from 91 to 56%, respectively. The Glasgow Microenvironment Score, a score based on KM grade and TSP, stratified survival from 93 to 58%. CONCLUSIONS: Although associated with increasing T stage, local and systemic tumour environment characteristics, and in particular Immunoscore, budding, TSP and mGPS, are stage-independent determinants of survival and may be utilised in the staging of patients with primary operable colorectal cancer. |*Tumor Microenvironment/immunology [MESH] |Aged [MESH] |Blood Vessels/pathology [MESH] |C-Reactive Protein/metabolism [MESH] |Colonic Neoplasms/*blood/*pathology/surgery [MESH] |Female [MESH] |Humans [MESH] |Lymphocyte Count [MESH] |Male [MESH] |Margins of Excision [MESH] |Middle Aged [MESH] |Neoplasm Grading [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Staging [MESH] |Neoplasm, Residual [MESH] |Neutrophils [MESH] |Rectal Neoplasms/*blood/*pathology/surgery [MESH]Tumour invasiveness, the local and systemic environment and the basis (epmc).pdf DeepDyve Pubget Overpricing