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10.1074/jbc.M117.797126 http://scihub22266oqcxt.onion/10.1074/jbc.M117.797126 C5519359!5519359 !28576828     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28576828 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2017 ; 292 (29 ): 12077-12087 Nephropedia Template TP {{tp|p=28576828 |t=2017. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome |pdf=|usr=}}{{28576828 }} gab.com Text The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1 transcription and activate the NLRP3 inflammasome JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28576828 #FOAvip The NLRP3 inflammasome is a multiprotein complex that regulates the activation of caspase-1 leading to the maturation of the proinflammatory cytokines IL-1? and IL-18 and promoting pyroptosis. Classically, the NLRP3 inflammasome in murine macrophages is activated by the recognition of pathogen-associated molecular patterns and by many structurally unrelated factors. Understanding the precise mechanism of NLRP3 activation by such a wide array of stimuli remains elusive, but several signaling events, including cytosolic efflux and influx of select ions, have been suggested. Accordingly, several studies have indicated a role of anion channels in NLRP3 inflammasome assembly, but their direct involvement has not been shown. Here, we report that the chloride intracellular channel proteins CLIC1 and CLIC4 participate in the regulation of the NLRP3 inflammasome. Confocal microscopy and cell fractionation experiments revealed that upon LPS stimulation of macrophages, CLIC1 and CLIC4 translocated into the nucleus and cellular membrane. In LPS/ATP-stimulated bone marrow-derived macrophages (BMDMs), CLIC1 or CLIC4 siRNA transfection impaired transcription of IL-1?, ASC speck formation, and secretion of mature IL-1?. Collectively, our results demonstrate that CLIC1 and CLIC4 participate both in the priming signal for IL-1? and in NLRP3 activation. Twit Text FOAVip The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1 transcription and activate the NLRP3 inflammasome ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28576828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28576828 #FOAvip English Wikipedia <ref>{{Cite pmid|28576828 }}</ref> The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome #MMPMID28576828 Domingo-Fernández R ; Coll RC ; Kearney J ; Breit S ; O'Neill LAJ J Biol Chem 2017[Jul]; 292 (29 ): 12077-12087 PMID28576828 show ga The NLRP3 inflammasome is a multiprotein complex that regulates the activation of caspase-1 leading to the maturation of the proinflammatory cytokines IL-1? and IL-18 and promoting pyroptosis. Classically, the NLRP3 inflammasome in murine macrophages is activated by the recognition of pathogen-associated molecular patterns and by many structurally unrelated factors. Understanding the precise mechanism of NLRP3 activation by such a wide array of stimuli remains elusive, but several signaling events, including cytosolic efflux and influx of select ions, have been suggested. Accordingly, several studies have indicated a role of anion channels in NLRP3 inflammasome assembly, but their direct involvement has not been shown. Here, we report that the chloride intracellular channel proteins CLIC1 and CLIC4 participate in the regulation of the NLRP3 inflammasome. Confocal microscopy and cell fractionation experiments revealed that upon LPS stimulation of macrophages, CLIC1 and CLIC4 translocated into the nucleus and cellular membrane. In LPS/ATP-stimulated bone marrow-derived macrophages (BMDMs), CLIC1 or CLIC4 siRNA transfection impaired transcription of IL-1?, ASC speck formation, and secretion of mature IL-1?. Collectively, our results demonstrate that CLIC1 and CLIC4 participate both in the priming signal for IL-1? and in NLRP3 activation. |Active Transport, Cell Nucleus/drug effects [MESH] |Animals [MESH] |Bone Marrow Cells/cytology/drug effects/immunology/metabolism [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Chloride Channels/antagonists & inhibitors/genetics/*metabolism [MESH] |Inflammasomes/*drug effects/immunology/metabolism [MESH] |Interleukin-1beta/*agonists/genetics/metabolism [MESH] |Lipopolysaccharides/toxicity [MESH] |Macrophage Activation/*drug effects [MESH] |Macrophages/cytology/*drug effects/immunology/metabolism [MESH] |Mice [MESH] |Mice, 129 Strain [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mitochondrial Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism [MESH] |Protein Transport/drug effects [MESH] |Pyroptosis/drug effects [MESH] |RAW 264.7 Cells [MESH] |RNA Interference [MESH]The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-(epmc).pdf DeepDyve Pubget Overpricing