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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 RNA+Biol 2017 ; 14 (6): 739-51 Nephropedia Template TP
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The Cajal body and the nucleolus: ?In a relationship? or ?It s complicated?? #MMPMID27661468
Trinkle-Mulcahy L; Sleeman JE
RNA Biol 2017[]; 14 (6): 739-51 PMID27661468show ga
From their initial identification as ?nucleolar accessory bodies? more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the 2 structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.