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10.1038/cr.2017.68 http://scihub22266oqcxt.onion/10.1038/cr.2017.68 C5518989!5518989 !28497810     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28497810 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Res 2017 ; 27 (7 ): 898-915 Nephropedia Template TP {{tp|p=28497810 |t=2017. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription |pdf=|usr=}}{{28497810 }} gab.com Text Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28497810 #FOAvip Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significant and functionally distinct from or redundant to histone acetylation. Here we present evidence that class I histone deacetylases (HDACs) rather than sirtuin family deacetylases (SIRTs) are the major histone decrotonylases, and that histone crotonylation is as dynamic as histone acetylation in mammalian cells. Notably, we have generated novel HDAC1 and HDAC3 mutants with impaired HDAC but intact HDCR activity. Using these mutants we demonstrate that selective HDCR in mammalian cells correlates with a broad transcriptional repression and diminished promoter association of crotonylation but not acetylation reader proteins. Furthermore, we show that histone crotonylation is enriched in and required for self-renewal of mouse embryonic stem cells. Twit Text FOAVip Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28497810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28497810 #FOAvip English Wikipedia <ref>{{Cite pmid|28497810 }}</ref> Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription #MMPMID28497810 Wei W ; Liu X ; Chen J ; Gao S ; Lu L ; Zhang H ; Ding G ; Wang Z ; Chen Z ; Shi T ; Li J ; Yu J ; Wong J Cell Res 2017[Jul]; 27 (7 ): 898-915 PMID28497810 show ga Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significant and functionally distinct from or redundant to histone acetylation. Here we present evidence that class I histone deacetylases (HDACs) rather than sirtuin family deacetylases (SIRTs) are the major histone decrotonylases, and that histone crotonylation is as dynamic as histone acetylation in mammalian cells. Notably, we have generated novel HDAC1 and HDAC3 mutants with impaired HDAC but intact HDCR activity. Using these mutants we demonstrate that selective HDCR in mammalian cells correlates with a broad transcriptional repression and diminished promoter association of crotonylation but not acetylation reader proteins. Furthermore, we show that histone crotonylation is enriched in and required for self-renewal of mouse embryonic stem cells. |*Transcription, Genetic [MESH] |Acetylation/drug effects [MESH] |Animals [MESH] |Cell Line [MESH] |Gene Expression [MESH] |Histone Deacetylase Inhibitors/metabolism [MESH] |Histone Deacetylases/genetics/*metabolism [MESH] |Histones/*metabolism [MESH] |Humans [MESH] |Hydroxamic Acids/pharmacology [MESH] |Lysine/metabolism [MESH] |Mice [MESH] |Mutant Proteins/genetics/metabolism [MESH] |Niacinamide/pharmacology [MESH] |Sirtuins/metabolism [MESH]Class I histone deacetylases are major histone decrotonylases: evidenc(epmc).pdf DeepDyve Pubget Overpricing