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10.1161/ATVBAHA.115.306710 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.115.306710 C5518796!5518796 !26586659     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26586659 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arterioscler+Thromb+Vasc+Biol 2016 ; 36 (1 ): 134-44 Nephropedia Template TP {{tp|p=26586659 |t=2016. Hypoxia-Inducible Factor 1? Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELM?)-Induced Pulmonary Hypertension |pdf=|usr=}}{{26586659 }} gab.com Text Hypoxia-Inducible Factor 1 Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELM )-Induced Pulmonary Hypertension JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=26586659 #FOAvip OBJECTIVE: Pulmonary hypertension (PH) is characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown that in rodents, hypoxia-induced mitogenic factor (HIMF; also known as FIZZ1 or resistin-like molecule-?) causes PH by initiating lung vascular inflammation. We hypothesized that hypoxia-inducible factor-1 (HIF-1) is a critical downstream signal mediator of HIMF during PH development. APPROACH AND RESULTS: In this study, we compared the degree of HIMF-induced pulmonary vascular remodeling and PH development in wild-type (HIF-1?(+/+)) and HIF-1? heterozygous null (HIF-1?(+/-)) mice. HIMF-induced PH was significantly diminished in HIF-1?(+/-) mice and was accompanied by a dysregulated vascular endothelial growth factor-A-vascular endothelial growth factor receptor 2 pathway. HIF-1? was critical for bone marrow-derived cell migration and vascular tube formation in response to HIMF. Furthermore, HIMF and its human homolog, resistin-like molecule-?, significantly increased interleukin (IL)-6 in macrophages and lung resident cells through a mechanism dependent on HIF-1? and, at least to some extent, on nuclear factor ?B. CONCLUSIONS: Our results suggest that HIF-1? is a critical downstream transcription factor for HIMF-induced pulmonary vascular remodeling and PH development. Importantly, both HIMF and human resistin-like molecule-? significantly increased IL-6 in lung resident cells and increased perivascular accumulation of IL-6-expressing macrophages in the lungs of mice. These data suggest that HIMF can induce HIF-1, vascular endothelial growth factor-A, and interleukin-6, which are critical mediators of both hypoxic inflammation and PH pathophysiology. Twit Text FOAVip Hypoxia-Inducible Factor 1 Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELM )-Induced Pulmonary Hypertension ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=26586659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26586659 #FOAvip English Wikipedia <ref>{{Cite pmid|26586659 }}</ref> Hypoxia-Inducible Factor 1? Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELM?)-Induced Pulmonary Hypertension #MMPMID26586659 Johns RA ; Takimoto E ; Meuchel LW ; Elsaigh E ; Zhang A ; Heller NM ; Semenza GL ; Yamaji-Kegan K Arterioscler Thromb Vasc Biol 2016[Jan]; 36 (1 ): 134-44 PMID26586659 show ga OBJECTIVE: Pulmonary hypertension (PH) is characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown that in rodents, hypoxia-induced mitogenic factor (HIMF; also known as FIZZ1 or resistin-like molecule-?) causes PH by initiating lung vascular inflammation. We hypothesized that hypoxia-inducible factor-1 (HIF-1) is a critical downstream signal mediator of HIMF during PH development. APPROACH AND RESULTS: In this study, we compared the degree of HIMF-induced pulmonary vascular remodeling and PH development in wild-type (HIF-1?(+/+)) and HIF-1? heterozygous null (HIF-1?(+/-)) mice. HIMF-induced PH was significantly diminished in HIF-1?(+/-) mice and was accompanied by a dysregulated vascular endothelial growth factor-A-vascular endothelial growth factor receptor 2 pathway. HIF-1? was critical for bone marrow-derived cell migration and vascular tube formation in response to HIMF. Furthermore, HIMF and its human homolog, resistin-like molecule-?, significantly increased interleukin (IL)-6 in macrophages and lung resident cells through a mechanism dependent on HIF-1? and, at least to some extent, on nuclear factor ?B. CONCLUSIONS: Our results suggest that HIF-1? is a critical downstream transcription factor for HIMF-induced pulmonary vascular remodeling and PH development. Importantly, both HIMF and human resistin-like molecule-? significantly increased IL-6 in lung resident cells and increased perivascular accumulation of IL-6-expressing macrophages in the lungs of mice. These data suggest that HIMF can induce HIF-1, vascular endothelial growth factor-A, and interleukin-6, which are critical mediators of both hypoxic inflammation and PH pathophysiology. |*Intercellular Signaling Peptides and Proteins/metabolism [MESH] |*Vascular Remodeling [MESH] |Animals [MESH] |Apoptosis [MESH] |Bone Marrow Transplantation [MESH] |Cell Movement [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Epithelial Cells/metabolism/pathology [MESH] |Female [MESH] |Fibroblasts/metabolism [MESH] |Genotype [MESH] |Hemodynamics [MESH] |Humans [MESH] |Hypertension, Pulmonary/chemically induced/genetics/*metabolism/physiopathology/prevention & control [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/deficiency/genetics/*metabolism [MESH] |In Vitro Techniques [MESH] |Inflammation Mediators/metabolism [MESH] |Interleukin-6/metabolism [MESH] |Macrophages/*metabolism/pathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Organ Culture Techniques [MESH] |Phenotype [MESH] |Pulmonary Artery/*metabolism/pathology/physiopathology [MESH] |Signal Transduction [MESH] |Vascular Endothelial Growth Factor A/metabolism [MESH]Hypoxia-Inducible Factor 1? Is a Critical Downstream Mediator for Hypo(epmc).pdf DeepDyve Pubget Overpricing