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10.1158/0008-5472.CAN-16-3383 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-3383 C5518753!5518753!28667073     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2017 ; 77 (14): 3740-4 Nephropedia Template TP {{tp|p=28667073|t=2017. Cancer cell autonomous parainflammation mimics immune cell infiltration |pdf=|usr=}}{{28667073}} gab.com Text Cancer cell autonomous parainflammation mimics immune cell infiltration JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28667073 #FOAvip Parainflammation is a unique variant of inflammation, characterized by epithelial-autonomous activation of inflammatory response. Parainflammation has been shown to strongly promote mouse gut tumorigenesis upon p53 loss. In a recent study, we explored the prevalence of parainflammation in human cancer and determined its relationship to certain molecular and clinical parameters affecting treatment and prognosis. Parainflammation can be identified from a 40-gene signature, and is found in both carcinoma cell lines and a variety of primary tumors, independently of tumor microenvironment. Here we discuss the implications of our findings in analyses of tumor microenvironment, suggesting that as tumor cell gene expression may often mimic immune and inflammatory infiltration, caution should be applied when interpreting tumor expression data. We also address the connection between parainflammation and prevalence of p53 mutations in specific types of tumors, and cancer prevention by regular usage of NSAIDs. We suggest that parainflammation may serve as a novel biomarker for screening patients who may particularly benefit from NSAID treatment. Twit Text FOAVip Cancer cell autonomous parainflammation mimics immune cell infiltration ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28667073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28667073 #FOAvip English Wikipedia <ref>{{Cite pmid|28667073}}</ref> Cancer cell autonomous parainflammation mimics immune cell infiltration #MMPMID28667073 Lasry A; Aran D; Butte AJ; Ben-Neriah Y Cancer Res 2017[Jul]; 77 (14): 3740-4 PMID28667073show ga Parainflammation is a unique variant of inflammation, characterized by epithelial-autonomous activation of inflammatory response. Parainflammation has been shown to strongly promote mouse gut tumorigenesis upon p53 loss. In a recent study, we explored the prevalence of parainflammation in human cancer and determined its relationship to certain molecular and clinical parameters affecting treatment and prognosis. Parainflammation can be identified from a 40-gene signature, and is found in both carcinoma cell lines and a variety of primary tumors, independently of tumor microenvironment. Here we discuss the implications of our findings in analyses of tumor microenvironment, suggesting that as tumor cell gene expression may often mimic immune and inflammatory infiltration, caution should be applied when interpreting tumor expression data. We also address the connection between parainflammation and prevalence of p53 mutations in specific types of tumors, and cancer prevention by regular usage of NSAIDs. We suggest that parainflammation may serve as a novel biomarker for screening patients who may particularly benefit from NSAID treatment. äCancer cell autonomous parainflammation mimics immune cell infiltratio(epmc).pdf DeepDyve Pubget Overpricing