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10.1097/MOH.0000000000000328 http://scihub22266oqcxt.onion/10.1097/MOH.0000000000000328 C5518670!5518670 !28099275     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28099275 &cmd=llinks): Failed to open stream: HTTP request failed! 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Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis |pdf=|usr=}}{{28099275 }} gab.com Text Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis JO: Curr Opin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=28099275 #FOAvip PURPOSE OF REVIEW: The erythroid progenitors burst-forming unit-erythroid and colony-forming unit-erythroid have a critical role in erythropoiesis. These cells represent a heterogeneous and poorly characterized population with modifiable self-renewal, proliferation and differentiation capabilities. This review focuses on the current state of erythroid progenitor biology with regard to immunophenotypic identification and regulatory programs. In addition, we will discuss the therapeutic implications of using these erythroid progenitors as pharmacologic targets. RECENT FINDINGS: Erythroid progenitors are classically characterized by the appearance of morphologically defined colonies in semisolid cultures. However, these prior systems preclude a more thorough understanding of the composite nature of progenitor populations. Recent studies employing novel flow cytometric and cell-based assays have helped to redefine hematopoiesis, and suggest that erythroid progenitors may arise from different levels of the hematopoietic tree. Moreover, the identification of cell surface marker patterns in human burst-forming unit-erythroid and colony-forming unit-erythroid enhance our ability to perform downstream functional and molecular analyses at the population and single cell level. Advances in these techniques have already revealed novel subpopulations with increased self-renewing capacity, roles for erythroid progenitors in globin gene expression, and insights into pharmacologic mechanisms of glucocorticoids and pomalidomide. SUMMARY: Immunophenotypic and molecular characterization resolves the diversity of erythroid progenitors, and may ultimately lead to the ability to target these progenitors to ameliorate diseases of dyserythropoiesis. Twit Text FOAVip Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis ????Curr Opin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=28099275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28099275 #FOAvip English Wikipedia <ref>{{Cite pmid|28099275 }}</ref> Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis #MMPMID28099275 Dulmovits BM ; Hom J ; Narla A ; Mohandas N ; Blanc L Curr Opin Hematol 2017[May]; 24 (3 ): 159-166 PMID28099275 show ga PURPOSE OF REVIEW: The erythroid progenitors burst-forming unit-erythroid and colony-forming unit-erythroid have a critical role in erythropoiesis. These cells represent a heterogeneous and poorly characterized population with modifiable self-renewal, proliferation and differentiation capabilities. This review focuses on the current state of erythroid progenitor biology with regard to immunophenotypic identification and regulatory programs. In addition, we will discuss the therapeutic implications of using these erythroid progenitors as pharmacologic targets. RECENT FINDINGS: Erythroid progenitors are classically characterized by the appearance of morphologically defined colonies in semisolid cultures. However, these prior systems preclude a more thorough understanding of the composite nature of progenitor populations. Recent studies employing novel flow cytometric and cell-based assays have helped to redefine hematopoiesis, and suggest that erythroid progenitors may arise from different levels of the hematopoietic tree. Moreover, the identification of cell surface marker patterns in human burst-forming unit-erythroid and colony-forming unit-erythroid enhance our ability to perform downstream functional and molecular analyses at the population and single cell level. Advances in these techniques have already revealed novel subpopulations with increased self-renewing capacity, roles for erythroid progenitors in globin gene expression, and insights into pharmacologic mechanisms of glucocorticoids and pomalidomide. SUMMARY: Immunophenotypic and molecular characterization resolves the diversity of erythroid progenitors, and may ultimately lead to the ability to target these progenitors to ameliorate diseases of dyserythropoiesis. |*Erythropoiesis/drug effects/genetics [MESH] |Anemia/drug therapy/*etiology/*metabolism/pathology [MESH] |Animals [MESH] |Biomarkers [MESH] |Cell Differentiation/drug effects/genetics [MESH] |Cell Proliferation/drug effects [MESH] |Cell Self Renewal/drug effects/genetics [MESH] |Erythroid Precursor Cells/*cytology/drug effects/*metabolism [MESH] |Glucocorticoids/pharmacology/therapeutic use [MESH] |Humans [MESH] |Immunologic Factors/pharmacology/therapeutic use [MESH] |Immunophenotyping [MESH] |Phenotype [MESH]Characterization, regulation, and targeting of erythroid progenitors i(epmc).pdf DeepDyve Pubget Overpricing