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10.1016/j.trecan.2017.03.003

http://scihub22266oqcxt.onion/10.1016/j.trecan.2017.03.003
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C5518481!5518481!28718438
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suck abstract from ncbi


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pmid28718438      Trends+Cancer 2017 ; 3 (4): 259-68
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  • Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis #MMPMID28718438
  • Tamori Y; Deng WM
  • Trends Cancer 2017[Apr]; 3 (4): 259-68 PMID28718438show ga
  • Epithelial tissues are highly organized systems with a remarkable homeostatic ability to maintain morphology through regulation of cellular proliferation and tissue integrity. This robust self-organizing system is progressively disrupted during tumor development. Recent studies of conserved tumor-suppressor genes in Drosophila showed how pro-tumor cells deviate from the robustly organized tissue microenvironment to take the first steps into becoming aggressive tumors. Here we review the ?tumor hotspot? hypothesis that explains how the tissue-intrinsic local microenvironment has a pivotal role in the initial stage of tumorigenesis in Drosophila epithelia and discuss comparable mechanisms in mammalian tissues.
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