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10.1007/s11912-017-0582-9 http://scihub22266oqcxt.onion/10.1007/s11912-017-0582-9 C5517131!5517131!28303495     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Oncol+Rep 2017 ; 19 (4): 28 Nephropedia Template TP {{tp|p=28303495|t=2017. Genetic Landscape and Classification of Peripheral T Cell Lymphomas |pdf=|usr=}}{{28303495}} gab.com Text Genetic Landscape and Classification of Peripheral T Cell Lymphomas JO: Curr Oncol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28303495 #FOAvip Purpose of review: Peripheral T cell lymphomas (PTCLs) are markedly heterogeneous at the clinical, pathological, and molecular levels. This review will discuss genetic findings in PTCL with special emphasis on how they impact lymphoma classification. Recent findings: Sequencing studies have identified recurrent genetic alterations in nearly every PTCL subtype. In anaplastic large cell lymphoma, these studies have revealed novel chromosomal rearrangements and mutations that have prognostic significance and may suggest new therapeutic approaches. Angioimmunoblastic T cell lymphoma has been found to have mutations overlapping some cases of PTCL, not otherwise specified with a T follicular helper cell phenotype. Across various subtypes, recurrent mutations and structural alterations affecting genes involved in epigenetic regulation, T cell receptor signaling, and immune response may represent targets for precision therapy approaches. Summary: New genetic findings are refining the classification of PTCLs and are beginning to be used clinically for diagnosis, risk stratification, and individualized therapy. Twit Text FOAVip Genetic Landscape and Classification of Peripheral T Cell Lymphomas ????Curr Oncol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28303495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28303495 #FOAvip English Wikipedia <ref>{{Cite pmid|28303495}}</ref> Genetic Landscape and Classification of Peripheral T Cell Lymphomas #MMPMID28303495 Sandell RF; Boddicker RL; Feldman AL Curr Oncol Rep 2017[Apr]; 19 (4): 28 PMID28303495show ga Purpose of review: Peripheral T cell lymphomas (PTCLs) are markedly heterogeneous at the clinical, pathological, and molecular levels. This review will discuss genetic findings in PTCL with special emphasis on how they impact lymphoma classification. Recent findings: Sequencing studies have identified recurrent genetic alterations in nearly every PTCL subtype. In anaplastic large cell lymphoma, these studies have revealed novel chromosomal rearrangements and mutations that have prognostic significance and may suggest new therapeutic approaches. Angioimmunoblastic T cell lymphoma has been found to have mutations overlapping some cases of PTCL, not otherwise specified with a T follicular helper cell phenotype. Across various subtypes, recurrent mutations and structural alterations affecting genes involved in epigenetic regulation, T cell receptor signaling, and immune response may represent targets for precision therapy approaches. Summary: New genetic findings are refining the classification of PTCLs and are beginning to be used clinically for diagnosis, risk stratification, and individualized therapy. äGenetic Landscape and Classification of Peripheral T Cell Lymphomas (epmc).pdf DeepDyve Pubget Overpricing