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10.1364/BOE.8.002261

http://scihub22266oqcxt.onion/10.1364/BOE.8.002261
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suck abstract from ncbi


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pmid28736670
      Biomed+Opt+Express 2017 ; 8 (4 ): 2261-2275
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  • Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging Invited #MMPMID28736670
  • Verstraete HRGW ; Heisler M ; Ju MJ ; Wahl D ; Bliek L ; Kalkman J ; Bonora S ; Jian Y ; Verhaegen M ; Sarunic MV
  • Biomed Opt Express 2017[Apr]; 8 (4 ): 2261-2275 PMID28736670 show ga
  • In this report, which is an international collaboration of OCT, adaptive optics, and control research, we demonstrate the Data-based Online Nonlinear Extremum-seeker (DONE) algorithm to guide the image based optimization for wavefront sensorless adaptive optics (WFSL-AO) OCT for in vivo human retinal imaging. The ocular aberrations were corrected using a multi-actuator adaptive lens after linearization of the hysteresis in the piezoelectric actuators. The DONE algorithm succeeded in drastically improving image quality and the OCT signal intensity, up to a factor seven, while achieving a computational time of 1 ms per iteration, making it applicable for many high speed applications. We demonstrate the correction of five aberrations using 70 iterations of the DONE algorithm performed over 2.8 s of continuous volumetric OCT acquisition. Data acquired from an imaging phantom and in vivo from human research volunteers are presented.
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