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10.1016/j.metabol.2017.04.005

http://scihub22266oqcxt.onion/10.1016/j.metabol.2017.04.005
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C5516622!5516622!28641779
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suck abstract from ncbi


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pmid28641779      Metabolism 2017 ; 72 (ä): 120-43
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  • Macrophage functions in lean and obese adipose tissue #MMPMID28641779
  • Thomas D; Apovian CM
  • Metabolism 2017[Jul]; 72 (ä): 120-43 PMID28641779show ga
  • Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction. This ultimately leads to adipose tissue fibrosis and diabetes. The molecular mechanisms underlying these processes have therapeutic implications for obesity, metabolic syndrome, and diabetes.
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