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10.1038/s41598-017-05741-y http://scihub22266oqcxt.onion/10.1038/s41598-017-05741-y C5515890!5515890!28720834     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28720834|t=2017. Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis |pdf=|usr=}}{{28720834}} gab.com Text Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28720834 #FOAvip Candida albicans is an opportunistic pathogen, typically found as a benign commensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infections. In debilitated and immunocompromised individuals, C. albicans may spread to cause life-threatening systemic infections. Upon contact with serum and at body temperature, C. albicans performs a regulated switch to filamentous morphology, characterized by emergence of a germ tube from the yeast cell followed by mold-like growth of branching hyphae. The ability to switch between growth morphologies is an important virulence factor of C. albicans. To identify compounds able to inhibit hyphal morphogenesis, we screened libraries of existing drugs for inhibition of the hyphal switch under stringent conditions. Several compounds that specifically inhibited hyphal morphogenesis were identified. Chemogenomic analysis suggested an interaction with the endocytic pathway, which was confirmed by direct measurement of fluid-phase endocytosis in the presence of these compounds. These results suggest that the activity of the endocytic pathway, which is known to be particularly important for hyphal growth, represents an effective target for hyphae-inhibiting drugs. Twit Text FOAVip Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28720834 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28720834 #FOAvip English Wikipedia <ref>{{Cite pmid|28720834}}</ref> Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis #MMPMID28720834 Bar-Yosef H; Vivanco Gonzalez N; Ben-Aroya S; Kron SJ; Kornitzer D Sci Rep 2017[]; 7 (ä): ä PMID28720834show ga Candida albicans is an opportunistic pathogen, typically found as a benign commensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infections. In debilitated and immunocompromised individuals, C. albicans may spread to cause life-threatening systemic infections. Upon contact with serum and at body temperature, C. albicans performs a regulated switch to filamentous morphology, characterized by emergence of a germ tube from the yeast cell followed by mold-like growth of branching hyphae. The ability to switch between growth morphologies is an important virulence factor of C. albicans. To identify compounds able to inhibit hyphal morphogenesis, we screened libraries of existing drugs for inhibition of the hyphal switch under stringent conditions. Several compounds that specifically inhibited hyphal morphogenesis were identified. Chemogenomic analysis suggested an interaction with the endocytic pathway, which was confirmed by direct measurement of fluid-phase endocytosis in the presence of these compounds. These results suggest that the activity of the endocytic pathway, which is known to be particularly important for hyphal growth, represents an effective target for hyphae-inhibiting drugs. äChemical inhibitors of Candida albicans hyphal morphogenesis target en(epmc).pdf DeepDyve Pubget Overpricing