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2017 ; 7
(1
): 5731
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Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor
imaging MRI with spin-echo sequence
#MMPMID28720778
Kaimori JY
; Isaka Y
; Hatanaka M
; Yamamoto S
; Ichimaru N
; Fujikawa A
; Shibata H
; Fujimori A
; Miyoshi S
; Yokawa T
; Kuroda K
; Moriyama T
; Rakugi H
; Takahara S
Sci Rep
2017[Jul]; 7
(1
): 5731
PMID28720778
show ga
Renal fibrosis (RF) is an indicator for progression of chronic kidney disease
(CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and
end-stage renal disease in Western populations, the ability of MRI to evaluate RF
in DN patients has not been determined. As a first step to identify possible MRI
methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI)
MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). The
signal-to-noise ratio in DTI MRI was enhanced using a spin-echo sequence, and a
special kidney attachment was developed for long-term stabilization. The changes
in renal temperature and blood flow during measurement were minimal, suggesting
the feasibility of this method. At 38 weeks of age, RF had aggressively
accumulated in the outer stripe (OS) of the outer medulla. FA maps showed that
this method was successful in visualizing and evaluating fibrosis in the OS of
the SHR/ND rat kidney (r?=?0.7697, P?=?0.0126). Interestingly, in the FA color
maps, the directions of water molecule diffusion in RF were random, but distinct
from conventional water diffusion in brain neuron fibers. These findings indicate
that DTI MRI may be able to evaluate RF in CKD by DN.
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