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10.4049/jimmunol.1700145 http://scihub22266oqcxt.onion/10.4049/jimmunol.1700145 C5515716!5515716!28539429     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28539429&cmd=llinks): Failed to open stream: HTTP request failed! 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Bolstering the Number and Function of HSV-1-Specific CD8+ TEM and TRM cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease |pdf=|usr=}}{{28539429}} gab.com Text Bolstering the Number and Function of HSV-1-Specific CD8+ TEM and TRM cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539429 #FOAvip Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen that infects over 3.72 billion individuals worldwide and can cause potentially blinding recurrent corneal herpetic disease. HSV-1 establishes latency within sensory neurons of trigeminal ganglia (TG) and TG-resident CD8+ T cells play a critical role in preventing its reactivation. The repertoire, phenotype and function of protective CD8+ T cells are unknown. Bolstering the apparent feeble numbers of CD8+ T cells in TG remains a challenge for immunotherapeutic strategies. In this study, a comprehensive panel of 467 HLA-A*0201-restricted CD8+ T cell epitopes were predicted from the entire HSV-1 genome. CD8+ T cell responses to these genome-wide epitopes were compared in HSV-1 seropositive symptomatic (SYMP) individuals (with a history of numerous episodes of recurrent herpetic disease) vs. asymptomatic (ASYMP) individuals (who are infected but never experienced any recurrent herpetic disease). Frequent polyfunctional HSV-specific effector memory IFN-?+CD107a/b+CD44highCD62LlowCD8+ TEM cells were detected in ASYMP individuals and were mainly directed against three ?ASYMP? epitopes. In contrast, SYMP individuals have more mono-functional central memory CD44highCD62LhighCD8+ TCM cells. Furthermore, therapeutic immunization with an innovative prime/pull vaccine, based on priming with multiple ?ASYMP? epitopes (prime) and neurotropic TG delivery of the T-cell attracting chemokine CXCL-10 (pull), boosted the number and function of CD44highCD62LlowCD8+ TEM and tissue-resident CD103highCD8+ TRM cells in TG of latently infected HLA-A*0201 Tg mice and reduced recurrent ocular herpes following UV-B induced reactivation. These findings have profound implications in the development of T-cell-based immunotherapeutic strategies to treat blinding recurrent herpes infection and disease. Twit Text FOAVip Bolstering the Number and Function of HSV-1-Specific CD8+ TEM and TRM cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28539429 #FOAvip English Wikipedia <ref>{{Cite pmid|28539429}}</ref> Bolstering the Number and Function of HSV-1-Specific CD8+ TEM and TRM cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease #MMPMID28539429 Khan AA; Srivastava R; Chentoufi AA; Kritzer E; Chilukuri S; Garg S; Yu DC; Vahed H; Huang L; Syed SA; Furness JN; Tran TT; Anthony NB; McLaren CE; Sidney J; Sette A; Noelle RJ; BenMohamed L J Immunol 2017[Jul]; 199 (1): 186-203 PMID28539429show ga Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen that infects over 3.72 billion individuals worldwide and can cause potentially blinding recurrent corneal herpetic disease. HSV-1 establishes latency within sensory neurons of trigeminal ganglia (TG) and TG-resident CD8+ T cells play a critical role in preventing its reactivation. The repertoire, phenotype and function of protective CD8+ T cells are unknown. Bolstering the apparent feeble numbers of CD8+ T cells in TG remains a challenge for immunotherapeutic strategies. In this study, a comprehensive panel of 467 HLA-A*0201-restricted CD8+ T cell epitopes were predicted from the entire HSV-1 genome. CD8+ T cell responses to these genome-wide epitopes were compared in HSV-1 seropositive symptomatic (SYMP) individuals (with a history of numerous episodes of recurrent herpetic disease) vs. asymptomatic (ASYMP) individuals (who are infected but never experienced any recurrent herpetic disease). Frequent polyfunctional HSV-specific effector memory IFN-?+CD107a/b+CD44highCD62LlowCD8+ TEM cells were detected in ASYMP individuals and were mainly directed against three ?ASYMP? epitopes. In contrast, SYMP individuals have more mono-functional central memory CD44highCD62LhighCD8+ TCM cells. Furthermore, therapeutic immunization with an innovative prime/pull vaccine, based on priming with multiple ?ASYMP? epitopes (prime) and neurotropic TG delivery of the T-cell attracting chemokine CXCL-10 (pull), boosted the number and function of CD44highCD62LlowCD8+ TEM and tissue-resident CD103highCD8+ TRM cells in TG of latently infected HLA-A*0201 Tg mice and reduced recurrent ocular herpes following UV-B induced reactivation. These findings have profound implications in the development of T-cell-based immunotherapeutic strategies to treat blinding recurrent herpes infection and disease. äBolstering the Number and Function of HSV-1-Specific CD8+ TEM and TRM (epmc).pdf DeepDyve Pubget Overpricing