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10.1016/j.jconrel.2017.05.009 http://scihub22266oqcxt.onion/10.1016/j.jconrel.2017.05.009 C5515481!5515481!28499816     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Control+Release 2017 ; 258 (ä): 67-72 Nephropedia Template TP {{tp|p=28499816|t=2017. Tumor ablation using low-intensity ultrasound and sound excitable drug |pdf=|usr=}}{{28499816}} gab.com Text Tumor ablation using low-intensity ultrasound and sound excitable drug JO: J Control Release http://www.kidney.de/pget.php?&tw=1&pmid=28499816 #FOAvip The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1 MHz, 1 W/cm2. The frequency and power density of insonation are within the physical therapy and medical imaging windows; thus the applied ultrasound is safe and not harmful to tissues. The insertion of SEDs into the plasma membrane is not toxic to cells; however, the intruding SEDs weaken the membrane?s integrity. Under insonation, the ultrasound energy destabilized the SED disrupted membranes, resulting in membrane rupture and eventual cell death. In a xenograft breast tumor model, the SED alone or the ultrasound alone caused little adverse effects to tumor tissue, while the combined treatment triggered necrosis with a brief local insonation of 3 minutes. The described sono-membrane rupture therapy could be a safe alternative to the currently used high-energy tissue ablation technology, which uses X-rays, gamma rays, electron beams, protons, or high- intensity focused ultrasound. Twit Text FOAVip Tumor ablation using low-intensity ultrasound and sound excitable drug ????J Control Release http://www.kidney.de/pget.php?&tw=1&pmid=28499816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28499816 #FOAvip English Wikipedia <ref>{{Cite pmid|28499816}}</ref> Tumor ablation using low-intensity ultrasound and sound excitable drug #MMPMID28499816 Tung CH; Han MS; Kim Y; Qi J; O?Neill BE J Control Release 2017[Jul]; 258 (ä): 67-72 PMID28499816show ga The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1 MHz, 1 W/cm2. The frequency and power density of insonation are within the physical therapy and medical imaging windows; thus the applied ultrasound is safe and not harmful to tissues. The insertion of SEDs into the plasma membrane is not toxic to cells; however, the intruding SEDs weaken the membrane?s integrity. Under insonation, the ultrasound energy destabilized the SED disrupted membranes, resulting in membrane rupture and eventual cell death. In a xenograft breast tumor model, the SED alone or the ultrasound alone caused little adverse effects to tumor tissue, while the combined treatment triggered necrosis with a brief local insonation of 3 minutes. The described sono-membrane rupture therapy could be a safe alternative to the currently used high-energy tissue ablation technology, which uses X-rays, gamma rays, electron beams, protons, or high- intensity focused ultrasound. äTumor ablation using low-intensity ultrasound and sound excitable drug(epmc).pdf DeepDyve Pubget Overpricing