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The Boosting Potential of Bacteria in Cancer Immunotherapy #MMPMID28583420
Binder DC; Wainwright DA
Trends Mol Med 2017[Jul]; 23 (7): 580-2 PMID28583420show ga
Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings for clinical applications, including immune checkpoint blockade therapies.