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10.18632/oncotarget.16467

http://scihub22266oqcxt.onion/10.18632/oncotarget.16467
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C5514966!5514966!28415635
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suck abstract from ncbi


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pmid28415635      Oncotarget 2017 ; 8 (23): 37974-90
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  • Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target #MMPMID28415635
  • Wen Y; Cai J; Hou Y; Huang Z; Wang Z
  • Oncotarget 2017[Jun]; 8 (23): 37974-90 PMID28415635show ga
  • Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance. Here, we review up-to-date information regarding EZH2 expression patterns, functions, and molecular mechanisms in cancer stem cells in various malignant tumors and discuss the therapeutic potential of targeting EZH2 in tumors.
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