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10.18632/oncotarget.17145 http://scihub22266oqcxt.onion/10.18632/oncotarget.17145 C5514943!5514943 !28465479     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28465479 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (23 ): 37717-37729 Nephropedia Template TP {{tp|p=28465479 |t=2017. KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling |pdf=|usr=}}{{28465479 }} gab.com Text KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28465479 #FOAvip A lack of effective prognostic biomarkers and molecular targets is a serious problem in hepatocellular carcinoma. KCTD11, reported as a tumor suppressor, are still not well understood. In this study, KCTD11 was found low-expressed in HCC tissues and cell lines. The HCC patients with low expression of KCTD11 suggested shorter overall survival. We found KCTD11 inhibiting cell proliferation in vitro and tumor growth in vivo, by activating p21 and repressing cycle related proteins. KCTD11 also inhibited cell adhesion by decreasing CTGF and CLDN1. We found CTGF binding COL3A1 in HCCLM3, which might lead to reduction of COL3A1 expression. KCTD11 also inhibited cell migration and invasion in HCC, by repressing MMPs and EMT. We found the tumor suppression function of KCTD11 was at least partly through activating Hippo pathway in HCC. Base on the enhanced Hippo pathway, KCTD11 could activate p21 by stabilizing p53 or promoting the MST1/ GSK3?/p21 signaling in HCC. Overall, these results suggest that KCTD11 works as a tumor suppressor and owns prognostic and therapeutic potentials in HCC. Twit Text FOAVip KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28465479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28465479 #FOAvip English Wikipedia <ref>{{Cite pmid|28465479 }}</ref> KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling #MMPMID28465479 Tong R ; Yang B ; Xiao H ; Peng C ; Hu W ; Weng X ; Cheng S ; Du C ; Lv Z ; Ding C ; Zhou L ; Xie H ; Wu J ; Zheng S Oncotarget 2017[Jun]; 8 (23 ): 37717-37729 PMID28465479 show ga A lack of effective prognostic biomarkers and molecular targets is a serious problem in hepatocellular carcinoma. KCTD11, reported as a tumor suppressor, are still not well understood. In this study, KCTD11 was found low-expressed in HCC tissues and cell lines. The HCC patients with low expression of KCTD11 suggested shorter overall survival. We found KCTD11 inhibiting cell proliferation in vitro and tumor growth in vivo, by activating p21 and repressing cycle related proteins. KCTD11 also inhibited cell adhesion by decreasing CTGF and CLDN1. We found CTGF binding COL3A1 in HCCLM3, which might lead to reduction of COL3A1 expression. KCTD11 also inhibited cell migration and invasion in HCC, by repressing MMPs and EMT. We found the tumor suppression function of KCTD11 was at least partly through activating Hippo pathway in HCC. Base on the enhanced Hippo pathway, KCTD11 could activate p21 by stabilizing p53 or promoting the MST1/ GSK3?/p21 signaling in HCC. Overall, these results suggest that KCTD11 works as a tumor suppressor and owns prognostic and therapeutic potentials in HCC. |Apoptosis [MESH] |Carcinoma, Hepatocellular/*genetics/pathology [MESH] |Cell Adhesion [MESH] |Cell Cycle Proteins [MESH] |Cell Proliferation [MESH] |Hippo Signaling Pathway [MESH] |Humans [MESH] |Liver Neoplasms/*genetics/pathology [MESH] |Neoplasm Metastasis [MESH] |Potassium Channels/*genetics/metabolism [MESH] |Prognosis [MESH] |Protein Serine-Threonine Kinases/*genetics [MESH] |Signal Transduction [MESH] |Transfection [MESH]KCTD11 inhibits growth and metastasis of hepatocellular carcinoma thro(epmc).pdf DeepDyve Pubget Overpricing