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2017 ; 35 Suppl 103
(1
): 98-101
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IgA antibodies to myeloperoxidase in patients with eosinophilic granulomatosis
with polyangiitis (Churg-Strauss)
#MMPMID28281453
Oommen E
; Hummel A
; Allmannsberger L
; Cuthbertson D
; Carette S
; Pagnoux C
; Hoffman GS
; Jenne DE
; Khalidi NA
; Koening CL
; Langford CA
; McAlear CA
; Moreland L
; Seo P
; Sreih A
; Ytterberg SR
; Merkel PA
; Specks U
; Monach PA
Clin Exp Rheumatol
2017[Mar]; 35 Suppl 103
(1
): 98-101
PMID28281453
show ga
OBJECTIVES: To determine the prevalence of anti-myeloperoxidase (MPO) antibodies
of IgA (IgA anti-MPO) isotype in patients with eosinophilic granulomatosis with
polyangiitis (EGPA), and the association of the IgA antibodies with IgG anti-MPO
and with disease activity. METHODS: Serum samples from patients with EGPA
followed in a multicenter longitudinal cohort were tested by ELISA for the
presence of IgA anti-MPO and IgG anti-MPO antibodies. Sera from 87 healthy
controls were used to define a positive test. Sera from 168 patients with EGPA
(298 samples) were tested. Frequencies of positive testing for IgA anti-MPO were
compared between patients with active EGPA, patients in remission, and controls.
RESULTS: IgA anti-MPO was detected in 10 of 168 (6%) patients with EGPA (11 of
298 serum samples) compared to 1 of 87 (1%) healthy controls (p=0.10). All 11
samples testing positive for IgA anti-MPO also tested positive for IgG anti-MPO.
Ninety samples tested positive for IgG anti-MPO but negative for IgA. Samples
taken during active EGPA were positive for IgA anti-MPO in 6/72 cases (8%),
compared to 5/226 (2%) during remission (p=0.03). Among samples taken during
moderate or high disease activity, 5/41 were positive (12%, p=0.01 compared to
remission). CONCLUSIONS: Although IgA anti-MPO antibodies are detectable in some
patients with EGPA and may be detectable more frequently during active disease,
their presence seems unlikely to provide information beyond what is obtained from
conventional IgG anti-MPO.
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