Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.yexcr.2017.04.016 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2017.04.016 C5514375!5514375!28433699     free     free     free       Exp+Cell+Res 2017 ; 356 (1): 93-103 Nephropedia Template TP {{tp|p=28433699|t=2017. EGFR-Mediated Apoptosis via STAT3 |pdf=|usr=}}{{28433699}} gab.com Text EGFR-Mediated Apoptosis via STAT3 JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28433699 #FOAvip The Epidermal Growth Factor Receptor (EGFR) is a cell surface receptor with primary implications in cell growth in both normal and malignant tissue. Paradoxically, cell lines that hyperexpress the EGFR have been documented to undergo receptor-mediated apoptosis. The underlying mechanism by which EGF-induced apoptosis occurs however remains inexplicit. In an attempt to identify this mechanism, we assessed downstream effectors of EGFR in MDA-MB-468 cells during conditions of EGF-induced apoptosis. The effector assessment revealed STAT3 as a potential mediator of EGF-induced apoptosis. Alternative strategies for activating STAT3, independent of EGFR stimulation, resulted in the induction of the apoptotic pathways. A reduction in STAT3 expression via RNAi resulted in a significant attenuation of EGF-induced PARP cleavage. Our findings support STAT3 as a positive mediator of EGF-induced apoptosis in MDA-MB-468 cells. Twit Text FOAVip EGFR-Mediated Apoptosis via STAT3 ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28433699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28433699 #FOAvip English Wikipedia <ref>{{Cite pmid|28433699}}</ref> EGFR-Mediated Apoptosis via STAT3 #MMPMID28433699 Jackson NM; Ceresa BP Exp Cell Res 2017[Jul]; 356 (1): 93-103 PMID28433699show ga The Epidermal Growth Factor Receptor (EGFR) is a cell surface receptor with primary implications in cell growth in both normal and malignant tissue. Paradoxically, cell lines that hyperexpress the EGFR have been documented to undergo receptor-mediated apoptosis. The underlying mechanism by which EGF-induced apoptosis occurs however remains inexplicit. In an attempt to identify this mechanism, we assessed downstream effectors of EGFR in MDA-MB-468 cells during conditions of EGF-induced apoptosis. The effector assessment revealed STAT3 as a potential mediator of EGF-induced apoptosis. Alternative strategies for activating STAT3, independent of EGFR stimulation, resulted in the induction of the apoptotic pathways. A reduction in STAT3 expression via RNAi resulted in a significant attenuation of EGF-induced PARP cleavage. Our findings support STAT3 as a positive mediator of EGF-induced apoptosis in MDA-MB-468 cells. äEGFR-Mediated Apoptosis via STAT3 (epmc).pdf DeepDyve Pubget Overpricing