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2017 ; 10
(ä): 3405-3419
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A comprehensive insight into the clinicopathologic significance of miR-144-3p in
hepatocellular carcinoma
#MMPMID28744145
Liang HW
; Ye ZH
; Yin SY
; Mo WJ
; Wang HL
; Zhao JC
; Liang GM
; Feng ZB
; Chen G
; Luo DZ
Onco Targets Ther
2017[]; 10
(ä): 3405-3419
PMID28744145
show ga
BACKGROUND: Studies which focused on the character of miR-144-3p in
hepatocellular carcinoma (HCC) are limited. This study aimed to explore the
expression, clinical significance and the potential targets of miR-144-3p in HCC.
METHODS: The Cancer Genome Atlas (TCGA) and a cohort of 95 cases of HCC were
applied to investigate aberrant miR-144-3p expression in HCC. A meta-analysis was
performed to accumulate data on miR-144-3p expression in HCC based on TCGA,
quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Gene
Expression Omnibus (GEO). Additionally, the potential regulatory mechanisms of
miR-144-3p in HCC were explored by bioinformatics. RESULTS: MiR-144-3p expression
was downregulated distinctly in HCC compared to para-HCC tissue both in TCGA data
(8.9139±1.5986 vs 10.7721±0.9156, P<0.001) and in our qRT-PCR validation
(1.3208±0.7594 vs 2.6200±0.9263, P<0.001). The meta-analysis based on TCGA,
qRT-PCR and GEO data confirmed a consistent result (standard mean difference
=-0.854, 95% CI: -1.224 to -0.484, P<0.001). The receiver operating
characteristic curve of miR-144-3p gained a significant diagnostic value both in
TCGA data (area under the curve [AUC] =0.852, 95% CI: 0.810 to 0.894, P<0.001)
and in qRT-PCR validation (AUC =0.867, 95% CI: 0.817 to 0.916, P<0.001),
especially in alpha-fetoprotein-negative HCC patients (AUC =0.900, 95% CI: 0.839
to 0.960, P<0.001). Furthermore, we identified 119 potential targets of
miR-144-3p in HCC by bioinformatics. Gene ontology and Kyoto Encyclopedia of
Genes and Genomes pathway analyses revealed that several significant biologic
functions and pathways correlated with the pathogenesis of HCC, including the p53
signaling pathway. CONCLUSION: MiR-144-3p may function as a cancer suppressor
microRNA, which is essential for HCC progression through the regulation of
various signaling pathways. Thus, interactions with miR-144-3p may provide a
novel treatment strategy for HCC in the future.
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