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2017 ; 12
(1
): 130
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
An update on the use of biologic therapies in the management of uveitis in
Behçet s disease: a comprehensive review
#MMPMID28716038
McNally TW
; Damato EM
; Murray PI
; Denniston AK
; Barry RJ
Orphanet J Rare Dis
2017[Jul]; 12
(1
): 130
PMID28716038
show ga
?: Behçet's disease (BD) is a systemic vasculitis characterised by a relapsing
remitting course, affecting multiple organ systems. In the eye, it is a cause of
potentially blinding inflammation in the form of uveitis. Management of uveitis
in BD often requires the use of systemic immunosuppression, in order to reduce
disease activity and prevent accumulation of irreversible damage. Whilst
corticosteroids remain the mainstay of treatment, long-term use is limited by the
development of adrenocorticotrophic side effects. There has therefore been
significant interest in the use of corticosteroid-sparing immunosuppressive
agents, and more recently, biologic therapies. Recent publications have
demonstrated biologic therapy to have beneficial effects both on overall disease
control, and quality of life for patients with BD. Widespread use of such agents
is however limited, partly by the lack of high quality research evidence, and
partly by the prohibitive cost of biologic treatments. In this review, we discuss
the most recent research investigating the use of biologic therapy in uveitis due
to BD, with consideration of health economics and quality of life outcomes.