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10.1016/j.immuni.2017.04.022 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.04.022 C5512722!5512722!28514688     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28514688.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2017 ; 46 (5): 818-834.e4 Nephropedia Template TP {{tp|p=28514688|t=2017. The E-Id Protein Axis Specifies Innate and Adaptive Lymphoid Cell Fate |pdf=|usr=}}{{28514688}} gab.com Text The E-Id Protein Axis Specifies Innate and Adaptive Lymphoid Cell Fate JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514688 #FOAvip Innate and adaptive lymphoid development is orchestrated by the activities of E-proteins and their antagonist Id-proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies we demonstrated that E-proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid tissue-inducer-like cells. E2A and HEB orchestrated T cell fate and suppressed the ILC transcription signature by activating the expression of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signaling. E2A and HEB acted in ETPs to establish and maintain a T cell-lineage specific enhancer repertoire, including regulatory elements associated with the Notch1 and Rag1/2 gene loci. Based on these and previous observations we propose that the E-Id protein axis specifies innate versus adaptive lymphoid cell fate. Twit Text FOAVip The E-Id Protein Axis Specifies Innate and Adaptive Lymphoid Cell Fate ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514688 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28514688 #FOAvip English Wikipedia <ref>{{Cite pmid|28514688}}</ref> The E-Id Protein Axis Specifies Innate and Adaptive Lymphoid Cell Fate #MMPMID28514688 Miyazaki M; Miyazaki K; Chen K; Jin Y; Turner J; Moore AJ; Saito R; Yoshida K; Ogawa S; Rodewald HR; Lin YC; Kawamoto H; Murre C Immunity 2017[May]; 46 (5): 818-834.e4 PMID28514688show ga Innate and adaptive lymphoid development is orchestrated by the activities of E-proteins and their antagonist Id-proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies we demonstrated that E-proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid tissue-inducer-like cells. E2A and HEB orchestrated T cell fate and suppressed the ILC transcription signature by activating the expression of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signaling. E2A and HEB acted in ETPs to establish and maintain a T cell-lineage specific enhancer repertoire, including regulatory elements associated with the Notch1 and Rag1/2 gene loci. Based on these and previous observations we propose that the E-Id protein axis specifies innate versus adaptive lymphoid cell fate. äThe E-Id Protein Axis Specifies Innate and Adaptive Lymphoid Cell Fate(epmc).pdf DeepDyve Pubget Overpricing