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10.1016/j.immuni.2017.04.022 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.04.022 C5512722!5512722 !28514688     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28514688 &cmd=llinks): Failed to open stream: HTTP request failed! 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The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development |pdf=|usr=}}{{28514688 }} gab.com Text The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514688 #FOAvip Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies, we demonstrated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid-tissue-inducer-like cells. E2A and HEB orchestrated T cell fate and suppressed the ILC transcription signature by activating the expression of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signaling. E2A and HEB acted in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including regulatory elements associated with the Notch1, Rag1, and Rag2 loci. On the basis of these and previous observations, we propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate. Twit Text FOAVip The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514688 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28514688 #FOAvip English Wikipedia <ref>{{Cite pmid|28514688 }}</ref> The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development #MMPMID28514688 Miyazaki M ; Miyazaki K ; Chen K ; Jin Y ; Turner J ; Moore AJ ; Saito R ; Yoshida K ; Ogawa S ; Rodewald HR ; Lin YC ; Kawamoto H ; Murre C Immunity 2017[May]; 46 (5 ): 818-834.e4 PMID28514688 show ga Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies, we demonstrated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid-tissue-inducer-like cells. E2A and HEB orchestrated T cell fate and suppressed the ILC transcription signature by activating the expression of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signaling. E2A and HEB acted in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including regulatory elements associated with the Notch1, Rag1, and Rag2 loci. On the basis of these and previous observations, we propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate. |*Adaptive Immunity [MESH] |*Immunity, Innate [MESH] |*Immunomodulation [MESH] |Animals [MESH] |Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism [MESH] |Cell Differentiation/immunology [MESH] |Cluster Analysis [MESH] |Gene Expression [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Gene Regulatory Networks [MESH] |Immunophenotyping [MESH] |Inhibitor of Differentiation Protein 2/genetics/metabolism [MESH] |Lymphocyte Activation/genetics/immunology [MESH] |Lymphocyte Subsets/cytology/*immunology/metabolism [MESH] |Lymphoid Progenitor Cells/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Phenotype [MESH] |T-Cell Antigen Receptor Specificity/immunology [MESH] |Thymocytes/cytology/*immunology/metabolism [MESH]The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Su(epmc).pdf DeepDyve Pubget Overpricing