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10.1097/CCM.0000000000002102 http://scihub22266oqcxt.onion/10.1097/CCM.0000000000002102 C5512699!5512699!27635771     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care+Med 2017 ; 45 (4): e426-32 Nephropedia Template TP {{tp|p=27635771|t=2017. Olfactomedin 4 is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock |pdf=|usr=}}{{27635771}} gab.com Text Olfactomedin 4 is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock JO: Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=27635771 #FOAvip Objectives: Heterogeneity in sepsis-related pathobiology presents a significant challenge. Resolving this heterogeneity presents an opportunity to understand pathobiology and improve patient care. Olfactomedin-4 (OLFM4) is a neutrophil subset marker and may contribute to sepsis heterogeneity. Our objective was to evaluate the expression of OLFM4 and characterize neutrophil heterogeneity in children with septic shock. Design: Single-center, prospective cohort, as well as secondary analysis of existing transcriptomic and proteomic databases. Setting: Tertiary care pediatric intensive care unit. Patients: Patients from age 5 days to 18 years with septic shock were enrolled. Data collected included the expression of OLFM4 mRNA, serum protein concentrations and percentage of neutrophils that express OLFM4. Interventions: None. Measurements and Main Results: Secondary analysis of existing transcriptomic data demonstrated that OLFM4 is the most highly expressed gene in non-survivors of pediatric septic shock, compared to survivors. Secondary analysis of an existing proteomic database corroborated these observations. In a prospectively enrolled cohort, we quantified the percentage of OLFM4+ neutrophils in patients with septic shock. Patients with a complicated course, defined as ?2 organ failures at day 7 of septic shock or 28-day mortality, had a higher percentage of OLFM4+ neutrophils, compared to those without a complicated course. By logistic regression, the percentage of OLFM4+ neutrophils was independently associated with increased risk of a complicated course (O.R. 1.09, 95% C.I. 1.01 to 1.17, p = 0.024). Conclusions: OLFM4 identifies a subpopulation of neutrophils in patients with septic shock, and those with a high percentage of OLFM4+ neutrophils are at higher risk for greater organ failure burden and death. OLFM4 might serve as a marker of a pathogenic neutrophil subset in patients with septic shock. Twit Text FOAVip Olfactomedin 4 is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock ????Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=27635771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27635771 #FOAvip English Wikipedia <ref>{{Cite pmid|27635771}}</ref> Olfactomedin 4 is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock #MMPMID27635771 Alder MN; Opoka AM; Lahni P; Hildeman DA; Wong HR Crit Care Med 2017[Apr]; 45 (4): e426-32 PMID27635771show ga Objectives: Heterogeneity in sepsis-related pathobiology presents a significant challenge. Resolving this heterogeneity presents an opportunity to understand pathobiology and improve patient care. Olfactomedin-4 (OLFM4) is a neutrophil subset marker and may contribute to sepsis heterogeneity. Our objective was to evaluate the expression of OLFM4 and characterize neutrophil heterogeneity in children with septic shock. Design: Single-center, prospective cohort, as well as secondary analysis of existing transcriptomic and proteomic databases. Setting: Tertiary care pediatric intensive care unit. Patients: Patients from age 5 days to 18 years with septic shock were enrolled. Data collected included the expression of OLFM4 mRNA, serum protein concentrations and percentage of neutrophils that express OLFM4. Interventions: None. Measurements and Main Results: Secondary analysis of existing transcriptomic data demonstrated that OLFM4 is the most highly expressed gene in non-survivors of pediatric septic shock, compared to survivors. Secondary analysis of an existing proteomic database corroborated these observations. In a prospectively enrolled cohort, we quantified the percentage of OLFM4+ neutrophils in patients with septic shock. Patients with a complicated course, defined as ?2 organ failures at day 7 of septic shock or 28-day mortality, had a higher percentage of OLFM4+ neutrophils, compared to those without a complicated course. By logistic regression, the percentage of OLFM4+ neutrophils was independently associated with increased risk of a complicated course (O.R. 1.09, 95% C.I. 1.01 to 1.17, p = 0.024). Conclusions: OLFM4 identifies a subpopulation of neutrophils in patients with septic shock, and those with a high percentage of OLFM4+ neutrophils are at higher risk for greater organ failure burden and death. OLFM4 might serve as a marker of a pathogenic neutrophil subset in patients with septic shock. äOlfactomedin 4 is a Candidate Marker for a Pathogenic Neutrophil Subse(epmc).pdf DeepDyve Pubget Overpricing