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10.1530/JME-17-0066 http://scihub22266oqcxt.onion/10.1530/JME-17-0066 C5512603!5512603!28559290     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Endocrinol 2017 ; 59 (1): 49-59 Nephropedia Template TP {{tp|p=28559290|t=2017. A Role for PFKFB3/iPFK2 in Metformin Suppression of Adipocyte Inflammatory Responses |pdf=|usr=}}{{28559290}} gab.com Text A Role for PFKFB3/iPFK2 in Metformin Suppression of Adipocyte Inflammatory Responses JO: J Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=28559290 #FOAvip Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation.Objective: To examine the direct effect of metformin on adipocyte inflammatory responses, and elucidate the underlying mechanisms. Methods: Adipocytes were differentiated from 3T3-L1 cells and treated with metformin at various doses and for different time periods. The treated cells were examined for the proinflammatory responses, as well as the phosphorylation states of AMPK and the expression of PFKFB3/iPFK2. In addition, PFKFB3/iPFK2-knockdown adipocytes were treated with metformin and examined for changes in the proinflammatory responses. Results: Treatment of adipocytes with metformin decreased the effects of lipopolysaccharide on inducing the phosphorylation states of JNK p46 and on increasing the mRNA levels of IL-1? and TNF?. In addition, treatment with metformin increased the expression of PFKFB3/iPFK2, but failed to significantly alter the phosphorylation states of AMPK. In PFKFB3/iPFK2-knockdown adipocytes, treatment with metformin did not suppress the proinflammatory responses as did it in control adipocytes. Conclusion: Metformin has a direct effect on suppressing adipocyte proinflammatory responses in an AMPK-independent manner. Also, metformin increases adipocyte expression of PFKFB3/iPFK2, which is involved in the anti-inflammatory effect of metformin. Twit Text FOAVip A Role for PFKFB3/iPFK2 in Metformin Suppression of Adipocyte Inflammatory Responses ????J Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=28559290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28559290 #FOAvip English Wikipedia <ref>{{Cite pmid|28559290}}</ref> A Role for PFKFB3/iPFK2 in Metformin Suppression of Adipocyte Inflammatory Responses #MMPMID28559290 Qi T; Chen Y; Li H; Pei Y; Woo SL; Guo X; Zhao J; Qian X; Awika J; Huo Y; Wu C J Mol Endocrinol 2017[Jul]; 59 (1): 49-59 PMID28559290show ga Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation.Objective: To examine the direct effect of metformin on adipocyte inflammatory responses, and elucidate the underlying mechanisms. Methods: Adipocytes were differentiated from 3T3-L1 cells and treated with metformin at various doses and for different time periods. The treated cells were examined for the proinflammatory responses, as well as the phosphorylation states of AMPK and the expression of PFKFB3/iPFK2. In addition, PFKFB3/iPFK2-knockdown adipocytes were treated with metformin and examined for changes in the proinflammatory responses. Results: Treatment of adipocytes with metformin decreased the effects of lipopolysaccharide on inducing the phosphorylation states of JNK p46 and on increasing the mRNA levels of IL-1? and TNF?. In addition, treatment with metformin increased the expression of PFKFB3/iPFK2, but failed to significantly alter the phosphorylation states of AMPK. In PFKFB3/iPFK2-knockdown adipocytes, treatment with metformin did not suppress the proinflammatory responses as did it in control adipocytes. Conclusion: Metformin has a direct effect on suppressing adipocyte proinflammatory responses in an AMPK-independent manner. Also, metformin increases adipocyte expression of PFKFB3/iPFK2, which is involved in the anti-inflammatory effect of metformin. äA Role for PFKFB3/iPFK2 in Metformin Suppression of Adipocyte Inflamma(epmc).pdf DeepDyve Pubget Overpricing