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10.1053/j.ackd.2017.04.001 http://scihub22266oqcxt.onion/10.1053/j.ackd.2017.04.001 C5512450!5512450!28501082     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Chronic+Kidney+Dis 2017 ; 24 (3): 183-8 Nephropedia Template TP {{tp|p=28501082|t=2017. A high-content screening technology for quantitatively studying podocyte dynamics |pdf=|usr=}}{{28501082}} gab.com Text A high-content screening technology for quantitatively studying podocyte dynamics JO: Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=28501082 #FOAvip Podocytes form the visceral layer of a renal glomerulus and express a characteristic octopus?like cellular architecture specialized for the ultrafiltration of blood. The cytoskeletal dynamics and structural elasticity of podocytes rely on the self-organization of highly interconnected actin bundles and the maintenance of these features is important for the intact glomerular filtration. Development of more differentiated podocytes in culture has dramatically increased our understanding of the molecular mechanisms regulating podocyte actin dynamics. Podocytes are damaged in a variety of kidney diseases and therapies targeting podocytes are being investigated with increasing efforts. Association between podocyte damage and disease severity?or between podocyte recovery and the performance of therapeutic molecules?have been the venues of research for years. In this perspective, more standardized high content screening (HCS) has emerged as a powerful tool for visualization and analysis of podocyte morphology. This high-throughput fluorescence microscopy technique is based on an automated image analysis with simultaneous detection of various phenotypes (multiplexing) across multiple phenotypic parameters (multiparametric). Here, we review the principles of HCS technology and summarize efforts to carry out small compound screen using podocytes. Twit Text FOAVip A high-content screening technology for quantitatively studying podocyte dynamics ????Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=28501082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28501082 #FOAvip English Wikipedia <ref>{{Cite pmid|28501082}}</ref> A high-content screening technology for quantitatively studying podocyte dynamics #MMPMID28501082 Reiser J; Lee HW; Gupta V; Altintas MM Adv Chronic Kidney Dis 2017[May]; 24 (3): 183-8 PMID28501082show ga Podocytes form the visceral layer of a renal glomerulus and express a characteristic octopus?like cellular architecture specialized for the ultrafiltration of blood. The cytoskeletal dynamics and structural elasticity of podocytes rely on the self-organization of highly interconnected actin bundles and the maintenance of these features is important for the intact glomerular filtration. Development of more differentiated podocytes in culture has dramatically increased our understanding of the molecular mechanisms regulating podocyte actin dynamics. Podocytes are damaged in a variety of kidney diseases and therapies targeting podocytes are being investigated with increasing efforts. Association between podocyte damage and disease severity?or between podocyte recovery and the performance of therapeutic molecules?have been the venues of research for years. In this perspective, more standardized high content screening (HCS) has emerged as a powerful tool for visualization and analysis of podocyte morphology. This high-throughput fluorescence microscopy technique is based on an automated image analysis with simultaneous detection of various phenotypes (multiplexing) across multiple phenotypic parameters (multiparametric). Here, we review the principles of HCS technology and summarize efforts to carry out small compound screen using podocytes. äA high-content screening technology for quantitatively studying podocy(epmc).pdf DeepDyve Pubget Overpricing