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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 DNA+Cell+Biol 2017 ; 36 (7): 513-7 Nephropedia Template TP
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ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity #MMPMID28594571
Li S; Fu B; Wang L; Dorf ME
DNA Cell Biol 2017[Jul]; 36 (7): 513-7 PMID28594571show ga
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common antiviral pathway that is associated with interferon-induced transmembrane proteins. In vivo studies with zmpste24-deficient mice demonstrate the importance of ZMPSTE24 for antiviral defense.