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10.1016/j.jare.2017.05.001

http://scihub22266oqcxt.onion/10.1016/j.jare.2017.05.001
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suck abstract from ncbi


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pmid28748122
      J+Adv+Res 2017 ; 8 (5 ): 555-560
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  • Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial #MMPMID28748122
  • Eleftheriadis T ; Golphinopoulos S ; Pissas G ; Stefanidis I
  • J Adv Res 2017[Sep]; 8 (5 ): 555-560 PMID28748122 show ga
  • Today there is plausible evidence both on experimental and epidemiological basis, that hyperuricemia represents a risk factor for the development and progression of chronic kidney disease (CKD). Nevertheless, the role of serum uric acid lowering treatment in CKD is still a matter of serious controversy. Review of randomised controlled trials, suggests that there may be an improvement of renal function with allopurinol treatment in CKD stage 3-5. However, these studies have included a relatively limited number of participants and provide insufficient information on adverse events and on the incidence of the end stage renal disease. Therefore, before adequately powered randomised, placebo-controlled trials are completed we cannot recommend treating asymptomatic hyperuricemia in patients with CKD.
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