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2017 ; 8
(5
): 555-560
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Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a
treatment controversial
#MMPMID28748122
Eleftheriadis T
; Golphinopoulos S
; Pissas G
; Stefanidis I
J Adv Res
2017[Sep]; 8
(5
): 555-560
PMID28748122
show ga
Today there is plausible evidence both on experimental and epidemiological basis,
that hyperuricemia represents a risk factor for the development and progression
of chronic kidney disease (CKD). Nevertheless, the role of serum uric acid
lowering treatment in CKD is still a matter of serious controversy. Review of
randomised controlled trials, suggests that there may be an improvement of renal
function with allopurinol treatment in CKD stage 3-5. However, these studies have
included a relatively limited number of participants and provide insufficient
information on adverse events and on the incidence of the end stage renal
disease. Therefore, before adequately powered randomised, placebo-controlled
trials are completed we cannot recommend treating asymptomatic hyperuricemia in
patients with CKD.