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10.1074/jbc.R117.776054

http://scihub22266oqcxt.onion/10.1074/jbc.R117.776054
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C5512057!5512057!28592486
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suck abstract from ncbi


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pmid28592486      J+Biol+Chem 2017 ; 292 (28): 11601-9
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  • Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) #MMPMID28592486
  • Bruntz RC; Lane AN; Higashi RM; Fan TWM
  • J Biol Chem 2017[Jul]; 292 (28): 11601-9 PMID28592486show ga
  • Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.
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