Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28704913
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Korean+J+Intern+Med
2017 ; 32
(4
): 600-610
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Treatment of connective tissue disease-associated interstitial lung disease: the
pulmonologist s point of view
#MMPMID28704913
Koo SM
; Uh ST
Korean J Intern Med
2017[Jul]; 32
(4
): 600-610
PMID28704913
show ga
Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular
disease (CVD), referred to as connective tissue disease (CTD). Despite advances
in management strategies, ILD continues to be a significant cause of mortality in
patients with CVD-associated ILD (CTD-ILD). There is a lack of randomized,
clinical trials assessing pharmacological agents for CTD-ILD, except in cases of
ILD-associated systemic sclerosis (SSc). This may be due to the lack of CTD cases
available, the difficulty of histological confirmation of ILD, and the various
types of CTD and ILD. As a result, evidence-based pharmacological treatment of
CTD-ILD is not yet well established. CTD-ILD presents with varying degrees of
histology, from inflammation to fibrosis, and a wide spectrum of clinical
manifestations, from minimal symptoms to respiratory failure. This renders it
difficult for clinicians to make decisions regarding treatment options,
observational strategies, optimal timing for interventions, and the
appropriateness of pharmacological agents for treatment. There is no specific
treatment for reversing fibrosis-like idiopathic pulmonary fibrosis in a clinical
setting. This review describes pharmacological interventions for SSc-ILD
described in randomized control trials, and presents an overview of recent
advances of CTD-ILD-dependent treatments based on the types of CTD.