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10.3389/fncel.2017.00210 http://scihub22266oqcxt.onion/10.3389/fncel.2017.00210 C5511838!5511838!28769767     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Neurosci 2017 ; 11 (ä): ä Nephropedia Template TP {{tp|p=28769767|t=2017. Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle |pdf=|usr=}}{{28769767}} gab.com Text Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle JO: Front Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28769767 #FOAvip During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells. Previous studies have shown that Panx1?/? mice possess severe disruption of the sleep-wake cycle. Here, we review experimental data supporting the involvement of pannexins (Panx) in the coordination of fundamental sleep-associated brain processes, such as neuronal activity and regulation of cerebrovascular tone. Panx1 hemichannels are likely implicated in the regulation of the sleep-wake cycle via an indirect effect of released ATP on adenosine receptors and through interaction with other somnogens, such as IL-1?, TNF? and prostaglandin D2. In addition to the recently established role of Panx1 in the regulation of endothelium-dependent arterial dilation, similar signaling pathways are the major cellular component of neurovascular coupling. The new discovered role of Panx in sleep regulation may have broad implications in coordinating neuronal activity and homeostatic housekeeping processes during the sleep-wake cycle. Twit Text FOAVip Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle ????Front Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28769767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28769767 #FOAvip English Wikipedia <ref>{{Cite pmid|28769767}}</ref> Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle #MMPMID28769767 Shestopalov VI; Panchin Y; Tarasova OS; Gaynullina D; Kovalzon VM Front Cell Neurosci 2017[]; 11 (ä): ä PMID28769767show ga During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells. Previous studies have shown that Panx1?/? mice possess severe disruption of the sleep-wake cycle. Here, we review experimental data supporting the involvement of pannexins (Panx) in the coordination of fundamental sleep-associated brain processes, such as neuronal activity and regulation of cerebrovascular tone. Panx1 hemichannels are likely implicated in the regulation of the sleep-wake cycle via an indirect effect of released ATP on adenosine receptors and through interaction with other somnogens, such as IL-1?, TNF? and prostaglandin D2. In addition to the recently established role of Panx1 in the regulation of endothelium-dependent arterial dilation, similar signaling pathways are the major cellular component of neurovascular coupling. The new discovered role of Panx in sleep regulation may have broad implications in coordinating neuronal activity and homeostatic housekeeping processes during the sleep-wake cycle. äPannexins Are Potential New Players in the Regulation of Cerebral Home(epmc).pdf DeepDyve Pubget Overpricing