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10.1097/ICU.0000000000000359 http://scihub22266oqcxt.onion/10.1097/ICU.0000000000000359 C5511789!5511789!28141764     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Ophthalmol 2017 ; 28 (3): 252-9 Nephropedia Template TP {{tp|p=28141764|t=2017. CRISPR Applications in Ophthalmologic Genome Surgery |pdf=|usr=}}{{28141764}} gab.com Text CRISPR Applications in Ophthalmologic Genome Surgery JO: Curr Opin Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=28141764 #FOAvip Purpose of review: This review seeks to summarize and discuss the application of CRISPR-Cas systems for genome editing, also called ?genome surgery,? in the field of ophthalmology. Recent findings: Precision medicine is an emerging approach for disease treatment and prevention that takes into account the variability of an individual?s genetic sequence. Various groups have used CRISPR-Cas genome editing to make significant progress in mammalian preclinical models of eye disease, the basic science of eye development in zebrafish, the in vivo modification of ocular tissue, as well as the correction of stem cells with therapeutic applications. Additionally, investigators have creatively used the targeted mutagenic potential of CRISPR-Cas systems to target pathogenic alleles in vitro. Summary: Over the past year, CRISPR-Cas genome editing has been used to correct pathogenic mutations in vivo as well as in transplantable stem cells. While off-target mutagenesis remains a concern, improvement in CRISPR-Cas technology and careful screening for undesired mutations will likely lead to clinical eye therapeutics employing CRISPR-Cas systems in the near future. Twit Text FOAVip CRISPR Applications in Ophthalmologic Genome Surgery ????Curr Opin Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=28141764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28141764 #FOAvip English Wikipedia <ref>{{Cite pmid|28141764}}</ref> CRISPR Applications in Ophthalmologic Genome Surgery #MMPMID28141764 Cabral T; DiCarlo JE; Justus S; Sengillo JD; Xu Y; Tsang SH Curr Opin Ophthalmol 2017[May]; 28 (3): 252-9 PMID28141764show ga Purpose of review: This review seeks to summarize and discuss the application of CRISPR-Cas systems for genome editing, also called ?genome surgery,? in the field of ophthalmology. Recent findings: Precision medicine is an emerging approach for disease treatment and prevention that takes into account the variability of an individual?s genetic sequence. Various groups have used CRISPR-Cas genome editing to make significant progress in mammalian preclinical models of eye disease, the basic science of eye development in zebrafish, the in vivo modification of ocular tissue, as well as the correction of stem cells with therapeutic applications. Additionally, investigators have creatively used the targeted mutagenic potential of CRISPR-Cas systems to target pathogenic alleles in vitro. Summary: Over the past year, CRISPR-Cas genome editing has been used to correct pathogenic mutations in vivo as well as in transplantable stem cells. While off-target mutagenesis remains a concern, improvement in CRISPR-Cas technology and careful screening for undesired mutations will likely lead to clinical eye therapeutics employing CRISPR-Cas systems in the near future. äCRISPR Applications in Ophthalmologic Genome Surgery (epmc).pdf DeepDyve Pubget Overpricing