Can Podocytes Be Regenerated in Adults? #MMPMID28306565
Shankland SJ; Freedman BS; Pippin JW
Curr Opin Nephrol Hypertens 2017[May]; 26 (3): 154-64 PMID28306565show ga
Podocytes are critical components of the nephron filtration barrier and are depleted in many kidney injuries and disease states. Terminally differentiated adult podocytes are highly specialized, post-mitotic cells, raising the question of whether the body has any ability to regenerate lost podocytes. Here, we review recent progress on this topic of significant interest and debate. The innovation of genetic labeling techniques enables fate tracing of individual podocytes, providing the strongest evidence yet that podocytes can be replaced by nearby progenitor cells. In particular, two progenitor pools have recently been identified in multiple studies: parietal epithelial cells (PECs), and cells of renin lineage (CoRL). These studies furthermore suggest that podocyte regeneration can be enhanced using ex vivo or pharmacological interventions. Based on these findings, we propose a set of criteria for evaluating podocyte regeneration, and suggest that restoration of podocyte number to a sub-sclerotic threshold be targeted as a potentially achievable clinical goal.
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Curr+Opin+Nephrol+Hypertens 2017 ; 26 (3): 154-64
