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10.1038/nrneph.2016.71 http://scihub22266oqcxt.onion/10.1038/nrneph.2016.71 C5510606!5510606!27241241     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Nephrol 2016 ; 12 (7): 402-13 Nephropedia Template TP {{tp|p=27241241|t=2016. The role of neutrophils and NETosis in autoimmune and renal diseases |pdf=|usr=}}{{27241241}} gab.com Text The role of neutrophils and NETosis in autoimmune and renal diseases JO: Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27241241 #FOAvip Systemic autoimmune diseases are a group of disorders characterized by a failure in self-tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these diseases occur as a multistep process in which environmental factors have key roles in the development of abnormal innate and adaptive immune responses. Experimental evidence collected in the past decade suggests that neutrophils ? the most abundant type of white blood cell ? might have an important role in the pathogenesis of these diseases by contributing to the initiation and perpetuation of immune dysregulation through the formation of neutrophil extracellular traps (NETs), synthesis of proinflammatory cytokines and direct tissue damage. Many of the molecules externalized through NET formation are considered to be key autoantigens and might be involved in the generation of autoimmune responses in predisposed individuals. In several systemic autoimmune diseases, the imbalance between NET formation and degradation might increase the half-life of these lattices, which could enhance the exposure of the immune system to modified autoantigens and increase the capacity for NET-induced organ damage. This Review details the role of neutrophils and NETs in the pathophysiology of systemic autoimmune diseases, including their effect on renal damage, and discusses neutrophil targets as potential novel therapies for these diseases. Twit Text FOAVip The role of neutrophils and NETosis in autoimmune and renal diseases ????Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27241241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27241241 #FOAvip English Wikipedia <ref>{{Cite pmid|27241241}}</ref> The role of neutrophils and NETosis in autoimmune and renal diseases #MMPMID27241241 Gupta S; Kaplan MJ Nat Rev Nephrol 2016[Jul]; 12 (7): 402-13 PMID27241241show ga Systemic autoimmune diseases are a group of disorders characterized by a failure in self-tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these diseases occur as a multistep process in which environmental factors have key roles in the development of abnormal innate and adaptive immune responses. Experimental evidence collected in the past decade suggests that neutrophils ? the most abundant type of white blood cell ? might have an important role in the pathogenesis of these diseases by contributing to the initiation and perpetuation of immune dysregulation through the formation of neutrophil extracellular traps (NETs), synthesis of proinflammatory cytokines and direct tissue damage. Many of the molecules externalized through NET formation are considered to be key autoantigens and might be involved in the generation of autoimmune responses in predisposed individuals. In several systemic autoimmune diseases, the imbalance between NET formation and degradation might increase the half-life of these lattices, which could enhance the exposure of the immune system to modified autoantigens and increase the capacity for NET-induced organ damage. This Review details the role of neutrophils and NETs in the pathophysiology of systemic autoimmune diseases, including their effect on renal damage, and discusses neutrophil targets as potential novel therapies for these diseases. äThe role of neutrophils and NETosis in autoimmune and renal diseases (epmc).pdf DeepDyve Pubget Overpricing