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10.1016/j.chembiol.2016.03.007 http://scihub22266oqcxt.onion/10.1016/j.chembiol.2016.03.007 C5510604!5510604!27049668     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Chem+Biol 2016 ; 23 (4): 483-93 Nephropedia Template TP {{tp|p=27049668|t=2016. Exogenous Fatty Acids are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts |pdf=|usr=}}{{27049668}} gab.com Text Exogenous Fatty Acids are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts JO: Cell Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=27049668 #FOAvip Cellular proliferation requires formation of additional cellular membrane material, and the current thinking in the field is that lipids required for this new membrane formation are mostly synthesized de novo. Here we measured the contribution of de novo lipid synthesis in proliferating and contact-inhibited fibroblasts and find that proliferating fibroblasts prefer exogenous palmitate over de novo synthesis. We determined that when exogenous palmitate is provided in culture media at physiological concentrations, de novo synthesis accounts for only ~10% of intracellular palmitate in proliferating fibroblasts, as well as HeLa and H460 lung cancer cells. Blocking fatty acid uptake decreased the rate of fibroblast, HeLa, and H460 cell proliferation, while supplementing media with exogenous palmitate resulted in decreased glucose uptake and rendered cells less sensitive to glycolytic inhibition. Thus, our results suggest that cells scavenging exogenous lipids may be less susceptible to both glycolytic and lipogenic inhibitors. Twit Text FOAVip Exogenous Fatty Acids are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts ????Cell Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=27049668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27049668 #FOAvip English Wikipedia <ref>{{Cite pmid|27049668}}</ref> Exogenous Fatty Acids are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts #MMPMID27049668 Yao CH; Grider RF; Mahieu NG; Liu GY; Chen YJ; Wang R; Singh M; Potter GS; Gross RW; Schaefer J; Johnson SL; Patti GJ Cell Chem Biol 2016[Apr]; 23 (4): 483-93 PMID27049668show ga Cellular proliferation requires formation of additional cellular membrane material, and the current thinking in the field is that lipids required for this new membrane formation are mostly synthesized de novo. Here we measured the contribution of de novo lipid synthesis in proliferating and contact-inhibited fibroblasts and find that proliferating fibroblasts prefer exogenous palmitate over de novo synthesis. We determined that when exogenous palmitate is provided in culture media at physiological concentrations, de novo synthesis accounts for only ~10% of intracellular palmitate in proliferating fibroblasts, as well as HeLa and H460 lung cancer cells. Blocking fatty acid uptake decreased the rate of fibroblast, HeLa, and H460 cell proliferation, while supplementing media with exogenous palmitate resulted in decreased glucose uptake and rendered cells less sensitive to glycolytic inhibition. Thus, our results suggest that cells scavenging exogenous lipids may be less susceptible to both glycolytic and lipogenic inhibitors. äExogenous Fatty Acids are the Preferred Source of Membrane Lipids in P(epmc).pdf DeepDyve Pubget Overpricing