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10.1038/nsmb.2842 http://scihub22266oqcxt.onion/10.1038/nsmb.2842 C5509563!5509563!24929436     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2014 ; 21 (7): 585-90 Nephropedia Template TP {{tp|p=24929436|t=2014. Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs |pdf=|usr=}}{{24929436}} gab.com Text Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=24929436 #FOAvip Long noncoding RNAs (lncRNAs) are important regulators of cell fate, yet little is known about mechanisms controlling lncRNA expression. Here we show that transcription is quantitatively different for lncRNAs and mRNAs?as revealed by deficiency of Dicer (Dcr), a key RNase that generates microRNAs (miRNAs). Dcr loss in mouse embryonic stem cells led unexpectedly to decreased levels of hundreds of lncRNAs. The canonical Dgcr8-Dcr-miRNA pathway is required for robust lncRNA transcriptional initiation and elongation. Computational and genetic epistasis analyses demonstrated that Dcr activation of the oncogenic transcription factor cMyc is partly responsible for lncRNA expression. A quantitative metric of mRNA-lncRNA decoupling revealed that Dcr and cMyc differentially regulate lncRNAs versus mRNAs in diverse cell types and in vivo. Thus, numerous lncRNAs may be modulated as a class in development and disease, notably where Dcr and cMyc act. Twit Text FOAVip Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=24929436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24929436 #FOAvip English Wikipedia <ref>{{Cite pmid|24929436}}</ref> Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs #MMPMID24929436 Zheng GXY; Do BT; Webster DE; Khavari PA; Chang HY Nat Struct Mol Biol 2014[Jul]; 21 (7): 585-90 PMID24929436show ga Long noncoding RNAs (lncRNAs) are important regulators of cell fate, yet little is known about mechanisms controlling lncRNA expression. Here we show that transcription is quantitatively different for lncRNAs and mRNAs?as revealed by deficiency of Dicer (Dcr), a key RNase that generates microRNAs (miRNAs). Dcr loss in mouse embryonic stem cells led unexpectedly to decreased levels of hundreds of lncRNAs. The canonical Dgcr8-Dcr-miRNA pathway is required for robust lncRNA transcriptional initiation and elongation. Computational and genetic epistasis analyses demonstrated that Dcr activation of the oncogenic transcription factor cMyc is partly responsible for lncRNA expression. A quantitative metric of mRNA-lncRNA decoupling revealed that Dcr and cMyc differentially regulate lncRNAs versus mRNAs in diverse cell types and in vivo. Thus, numerous lncRNAs may be modulated as a class in development and disease, notably where Dcr and cMyc act. äDicer-microRNA-Myc circuit promotes transcription of hundreds of long (epmc).pdf DeepDyve Pubget Overpricing