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2010 ; 10
(2
): 84-8
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Ultrasound measurement of peripheral endothelial dysfunction in type 2 diabetic
patients: correlation with risk factors
#MMPMID20507285
Bosevski M
; Georgievska-Ismail L
Bosn J Basic Med Sci
2010[May]; 10
(2
): 84-8
PMID20507285
show ga
The purpose of the study was to assess the endothelial dysfunction (ED) in type 2
diabetic patients ultrasonographically and estimate the correlation of ED with
glycemia and other cardio-metabolic risk factors. 171 patient (age 60.0 + 8.5
years) with diagnosed type 2 diabetes and coronary artery disease (CAD) were
randomly included in a cross sectional study. B-mode ultrasound system with a
linear transducer of 7.5 MHz was used for evaluation of flow-mediated
vasodilation in brachial artery (FMV). FMV was presented as a change of brachial
artery diameter at rest and after limb ischemia, previously provoked by cuff
inflation. Peripheral ED was found in 77.2% (132 patients). Multivariate logistic
regression model defined: age (OR 1.071, 95% CI 1.003 1,143) and plasma
cholesterol (OR 4.083 95% CI 1.080 17,017) as determinants for ED. Linear
multivariate analysis presented duration of diabetes (Beta 0.173, Sig 0.024), and
glycemia (Beta 0.132, Sig 0.044) to be associated independently with FMV value.
Estimated factors influencing FMV, might be potential therapeutic targets for
presented endothelial dysfunction in type 2 diabetic patients with coronary
artery disease.