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http://scihub22266oqcxt.onion/ C5509337!5509337!26202204     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mini+Rev+Med+Chem 2016 ; 16 (6): 430-54 Nephropedia Template TP {{tp|p=26202204|t=2016. Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma |pdf=|usr=}}{{26202204}} gab.com Text Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma JO: Mini Rev Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26202204 #FOAvip While mortality is low for intraocular retinoblastoma patients in the developed world who receive aggressive multimodal therapy, partial or full loss of vision occurs in approximately 50% of patients with advanced bilateral retinoblastoma. Therapies that preserve vision and reduce late effects are needed. Because clinical trials for retinoblastoma are difficult due to the young age of the patient population and relative rarity of the disease, robust preclinical testing of new therapies is critical. The last decade has seen advances towards identifying new therapies including the development of animal models of retinoblastoma for preclinical testing, progress in local drug delivery to reach intraocular targets, and improved understanding of the underlying biological mechanisms that give rise to retinoblastoma. This review discusses advances in these areas, with a focus on discovery and development of small molecules for the treatment of retinoblastoma, including novel targeted therapeutics such as inhibitors of the MDMX-p53 interaction (nutlin-3a), histone deacetylase (HDAC) inhibitors, and spleen tyrosine kinase (SYK) inhibitors. Twit Text FOAVip Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma ????Mini Rev Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26202204 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26202204 #FOAvip English Wikipedia <ref>{{Cite pmid|26202204}}</ref> Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma #MMPMID26202204 Pritchard EM; Dyer MA; Guy RK Mini Rev Med Chem 2016[]; 16 (6): 430-54 PMID26202204show ga While mortality is low for intraocular retinoblastoma patients in the developed world who receive aggressive multimodal therapy, partial or full loss of vision occurs in approximately 50% of patients with advanced bilateral retinoblastoma. Therapies that preserve vision and reduce late effects are needed. Because clinical trials for retinoblastoma are difficult due to the young age of the patient population and relative rarity of the disease, robust preclinical testing of new therapies is critical. The last decade has seen advances towards identifying new therapies including the development of animal models of retinoblastoma for preclinical testing, progress in local drug delivery to reach intraocular targets, and improved understanding of the underlying biological mechanisms that give rise to retinoblastoma. This review discusses advances in these areas, with a focus on discovery and development of small molecules for the treatment of retinoblastoma, including novel targeted therapeutics such as inhibitors of the MDMX-p53 interaction (nutlin-3a), histone deacetylase (HDAC) inhibitors, and spleen tyrosine kinase (SYK) inhibitors. äProgress in Small Molecule Therapeutics for the Treatment of Retinobla(epmc).pdf DeepDyve Pubget Overpricing