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10.4269/ajtmh.16-0845

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suck abstract from ncbi


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pmid28719302
      Am+J+Trop+Med+Hyg 2017 ; 97 (1 ): 125-129
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  • A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil #MMPMID28719302
  • de Oliveira RC ; Guterres A ; Teixeira BR ; Fernandes J ; Júnior JMP ; de Jesus Oliveira Júnior R ; Pereira LS ; Júnior JB ; Meneguete PS ; Dias CMG ; Bonvicino CR ; D'Andrea PS ; de Lemos ERS
  • Am J Trop Med Hyg 2017[Jul]; 97 (1 ): 125-129 PMID28719302 show ga
  • We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing. Antibody prevalence was 6.9%. The circulation of a single genotype, the Juquitiba hantavirus, carried by two rodent species, black-footed pigmy rice rat (Oligoryzomys nigripes) and cursor grass mouse (Akodon cursor), was shown by analysis of the nucleotide sequences of the S segment. Juquitiba hantavirus circulates in rodents of various species, but mainly in the black-footed pigmy rice rat. HPS is a newly recognized clinical entity in Rio de Janeiro State and should be considered in patients with febrile illness and acute respiratory distress.
  • |*Diagnostic Errors [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Animals [MESH]
  • |Antibodies, Viral/*blood [MESH]
  • |Base Sequence [MESH]
  • |Brazil/epidemiology [MESH]
  • |Dengue/*diagnosis [MESH]
  • |Disease Reservoirs/*virology [MESH]
  • |Enzyme-Linked Immunosorbent Assay [MESH]
  • |Female [MESH]
  • |Hantavirus Pulmonary Syndrome/*diagnosis/epidemiology/*mortality [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Orthohantavirus/isolation & purification [MESH]
  • |Prevalence [MESH]
  • |RNA, Viral/blood [MESH]
  • |Rodentia/*virology [MESH]


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