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2017 ; 8
(7
): 3248-3280
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gab.com Text
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Twenty-five years of optical coherence tomography: the paradigm shift in
sensitivity and speed provided by Fourier domain OCT Invited
#MMPMID28717565
de Boer JF
; Leitgeb R
; Wojtkowski M
Biomed Opt Express
2017[Jul]; 8
(7
): 3248-3280
PMID28717565
show ga
Optical coherence tomography (OCT) has become one of the most successful optical
technologies implemented in medicine and clinical practice mostly due to the
possibility of non-invasive and non-contact imaging by detecting back-scattered
light. OCT has gone through a tremendous development over the past 25 years. From
its initial inception in 1991 [Science254, 1178 (1991)] it has become an
indispensable medical imaging technology in ophthalmology. Also in fields like
cardiology and gastro-enterology the technology is envisioned to become a
standard of care. A key contributor to the success of OCT has been the
sensitivity and speed advantage offered by Fourier domain OCT. In this review
paper the development of FD-OCT will be revisited, providing a single
comprehensive framework to derive the sensitivity advantage of both SD- and
SS-OCT. We point out the key aspects of the physics and the technology that has
enabled a more than 2 orders of magnitude increase in sensitivity, and as a
consequence an increase in the imaging speed without loss of image quality. This
speed increase provided a paradigm shift from point sampling to comprehensive 3D
in vivo imaging, whose clinical impact is still actively explored by a large
number of researchers worldwide.