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10.1016/j.devcel.2017.04.024 http://scihub22266oqcxt.onion/10.1016/j.devcel.2017.04.024 C5508591!5508591!28535374     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2017 ; 41 (4): 392-407.e6 Nephropedia Template TP {{tp|p=28535374|t=2017. Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation |pdf=|usr=}}{{28535374}} gab.com Text Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535374 #FOAvip Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a C. elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent ?Ras pathway-sensitized? epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation and translation. Stromal fibroblast-specific deletion of candidate mouse orthologs of several candidates resulted in the hyperproliferation of mammary gland epithelium. Furthermore, a 33-gene signature of human orthologs was selectively enriched in the tumor stroma of breast cancer patients and depletion of these factors from normal human breast fibroblasts increased proliferation of co-cultured breast cancer cells. This cross-species approach identified unanticipated regulatory networks in mesodermal cells with growth suppressive function, exposing the conserved and selective nature of mesodermal-epithelial communication in development and cancer. Twit Text FOAVip Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28535374 #FOAvip English Wikipedia <ref>{{Cite pmid|28535374}}</ref> Discovery of stromal regulatory networks that suppress Ras-sensitized epithelial cell proliferation #MMPMID28535374 Liu H; Dowdle JA; Khurshid S; Sullivan NJ; Bertos N; Rambani K; Mair M; Daniel P; Wheeler E; Tang X; Toth K; Lause M; Harrigan ME; Eiring K; Sullivan C; Sullivan MJ; Chang SW; Srivastava S; Conway JS; Kladney R; McElroy J; Bae S; Lu Y; Tofigh A; Saleh SMI; Fernandez SA; Parvin JD; Coppola V; Macrae ER; Majumder S; Shapiro CL; Yee LD; Ramaswamy B; Hallett M; Ostrowski MC; Park M; Chamberlin HM; Leone G Dev Cell 2017[May]; 41 (4): 392-407.e6 PMID28535374show ga Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a C. elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent ?Ras pathway-sensitized? epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation and translation. Stromal fibroblast-specific deletion of candidate mouse orthologs of several candidates resulted in the hyperproliferation of mammary gland epithelium. Furthermore, a 33-gene signature of human orthologs was selectively enriched in the tumor stroma of breast cancer patients and depletion of these factors from normal human breast fibroblasts increased proliferation of co-cultured breast cancer cells. This cross-species approach identified unanticipated regulatory networks in mesodermal cells with growth suppressive function, exposing the conserved and selective nature of mesodermal-epithelial communication in development and cancer. äDiscovery of stromal regulatory networks that suppress Ras-sensitized (epmc).pdf DeepDyve Pubget Overpricing