Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.devcel.2017.04.024 http://scihub22266oqcxt.onion/10.1016/j.devcel.2017.04.024 C5508591!5508591 !28535374     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28535374 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28535374 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dev+Cell 2017 ; 41 (4 ): 392-407.e6 Nephropedia Template TP {{tp|p=28535374 |t=2017. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation |pdf=|usr=}}{{28535374 }} gab.com Text Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535374 #FOAvip Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent Ras pathway-sensitized epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation, and translation. Stromal fibroblast-specific deletion of mouse orthologs of several candidates resulted in the hyper-proliferation of mammary gland epithelium. Furthermore, a 33-gene signature of human orthologs was selectively enriched in the tumor stroma of breast cancer patients, and depletion of these factors from normal human breast fibroblasts increased proliferation of co-cultured breast cancer cells. This cross-species approach identified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, exposing the conserved and selective nature of mesodermal-epithelial communication in development and cancer. Twit Text FOAVip Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28535374 #FOAvip English Wikipedia <ref>{{Cite pmid|28535374 }}</ref> Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation #MMPMID28535374 Liu H ; Dowdle JA ; Khurshid S ; Sullivan NJ ; Bertos N ; Rambani K ; Mair M ; Daniel P ; Wheeler E ; Tang X ; Toth K ; Lause M ; Harrigan ME ; Eiring K ; Sullivan C ; Sullivan MJ ; Chang SW ; Srivastava S ; Conway JS ; Kladney R ; McElroy J ; Bae S ; Lu Y ; Tofigh A ; Saleh SMI ; Fernandez SA ; Parvin JD ; Coppola V ; Macrae ER ; Majumder S ; Shapiro CL ; Yee LD ; Ramaswamy B ; Hallett M ; Ostrowski MC ; Park M ; Chamberlin HM ; Leone G Dev Cell 2017[May]; 41 (4 ): 392-407.e6 PMID28535374 show ga Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent Ras pathway-sensitized epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation, and translation. Stromal fibroblast-specific deletion of mouse orthologs of several candidates resulted in the hyper-proliferation of mammary gland epithelium. Furthermore, a 33-gene signature of human orthologs was selectively enriched in the tumor stroma of breast cancer patients, and depletion of these factors from normal human breast fibroblasts increased proliferation of co-cultured breast cancer cells. This cross-species approach identified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, exposing the conserved and selective nature of mesodermal-epithelial communication in development and cancer. |*Gene Regulatory Networks [MESH] |Animals [MESH] |Breast Neoplasms/genetics/pathology [MESH] |Caenorhabditis elegans Proteins/metabolism [MESH] |Caenorhabditis elegans/cytology/metabolism [MESH] |Cell Lineage [MESH] |Cell Proliferation [MESH] |Epithelial Cells/*cytology/*metabolism [MESH] |Female [MESH] |Fibroblasts/metabolism/pathology [MESH] |Gene Expression Profiling [MESH] |Genome [MESH] |Humans [MESH] |Mammary Glands, Animal/cytology [MESH] |Mesoderm/metabolism [MESH] |Mice [MESH] |Mutation/genetics [MESH] |Nuclear Proteins [MESH] |Organ Specificity [MESH] |Phenotype [MESH] |Protein Kinases [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |RNA Interference [MESH] |Signal Transduction/genetics [MESH] |Stromal Cells/cytology/metabolism [MESH] |ras GTPase-Activating Proteins/metabolism [MESH]Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized (epmc).pdf DeepDyve Pubget Overpricing