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10.1146/annurev-biophys-050511-102252

http://scihub22266oqcxt.onion/10.1146/annurev-biophys-050511-102252
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C5508560!5508560!22404683
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suck abstract from ncbi

pmid22404683      Annu+Rev+Biophys 2012 ; 41 (ä): 227-46
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  • Filamins in mechanosensing and signaling #MMPMID22404683
  • Razinia Z; Mäkelä T; Ylänne J; Calderwood DA
  • Annu Rev Biophys 2012[]; 41 (ä): 227-46 PMID22404683show ga
  • Filamins are essential, evolutionary conserved, modular, multi-domain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors. By crosslinking and anchoring actin filaments, filamins stabilize the plasma membrane, provide cellular cortical rigidity and contribute to the mechanical stability of the plasma membrane and the cell cortex. In addition to actin, filamins interact with over 90 other binding partners including intracellular signaling molecules, receptors, ion channels, transcriptions factors and cytoskeletal and adhesion proteins. Thus, filamins scaffold a wide range of signaling pathways and are implicated in the regulation of a diverse array of cellular functions including motility, maintenance of cell shape and differentiation. Here, we review emerging structural and functional evidence that filamins are mechanosensors and/or mechanotransducers, playing essential roles in helping cells to detect and respond to physical forces in their local environment.
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