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10.1038/ncomms16002 http://scihub22266oqcxt.onion/10.1038/ncomms16002 C5508205!5508205!28695891     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28695891|t=2017. The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability |pdf=|usr=}}{{28695891}} gab.com Text The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28695891 #FOAvip Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates Ang1-dependent regulation of Notch ligands and is required for the stabilizing effects of Ang1 in vivo. We show that Ang1 induces ERG phosphorylation in a phosphoinositide 3-kinase (PI3K)/Akt-dependent manner, resulting in ERG enrichment at Dll4 promoter and multiple enhancers. Finally, we demonstrate that ERG directly interacts with Notch intracellular domain (NICD) and ?-catenin and is required for Ang1-dependent ?-catenin recruitment at the Dll4 locus. We propose that ERG coordinates Ang1, ?-catenin and Notch signalling to promote vascular stability. Twit Text FOAVip The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28695891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28695891 #FOAvip English Wikipedia <ref>{{Cite pmid|28695891}}</ref> The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability #MMPMID28695891 Shah AV; Birdsey GM; Peghaire C; Pitulescu ME; Dufton NP; Yang Y; Weinberg I; Osuna Almagro L; Payne L; Mason JC; Gerhardt H; Adams RH; Randi AM Nat Commun 2017[]; 8 (ä): ä PMID28695891show ga Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates Ang1-dependent regulation of Notch ligands and is required for the stabilizing effects of Ang1 in vivo. We show that Ang1 induces ERG phosphorylation in a phosphoinositide 3-kinase (PI3K)/Akt-dependent manner, resulting in ERG enrichment at Dll4 promoter and multiple enhancers. Finally, we demonstrate that ERG directly interacts with Notch intracellular domain (NICD) and ?-catenin and is required for Ang1-dependent ?-catenin recruitment at the Dll4 locus. We propose that ERG coordinates Ang1, ?-catenin and Notch signalling to promote vascular stability. äThe endothelial transcription factor ERG mediates Angiopoietin-1-depen(epmc).pdf DeepDyve Pubget Overpricing