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10.1038/ncomms16002 http://scihub22266oqcxt.onion/10.1038/ncomms16002 C5508205!5508205 !28695891     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28695891 &cmd=llinks): Failed to open stream: HTTP request failed! 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The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability |pdf=|usr=}}{{28695891 }} gab.com Text The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28695891 #FOAvip Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates Ang1-dependent regulation of Notch ligands and is required for the stabilizing effects of Ang1 in vivo. We show that Ang1 induces ERG phosphorylation in a phosphoinositide 3-kinase (PI3K)/Akt-dependent manner, resulting in ERG enrichment at Dll4 promoter and multiple enhancers. Finally, we demonstrate that ERG directly interacts with Notch intracellular domain (NICD) and ?-catenin and is required for Ang1-dependent ?-catenin recruitment at the Dll4 locus. We propose that ERG coordinates Ang1, ?-catenin and Notch signalling to promote vascular stability. Twit Text FOAVip The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28695891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28695891 #FOAvip English Wikipedia <ref>{{Cite pmid|28695891 }}</ref> The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability #MMPMID28695891 Shah AV ; Birdsey GM ; Peghaire C ; Pitulescu ME ; Dufton NP ; Yang Y ; Weinberg I ; Osuna Almagro L ; Payne L ; Mason JC ; Gerhardt H ; Adams RH ; Randi AM Nat Commun 2017[Jul]; 8 (ä): 16002 PMID28695891 show ga Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates Ang1-dependent regulation of Notch ligands and is required for the stabilizing effects of Ang1 in vivo. We show that Ang1 induces ERG phosphorylation in a phosphoinositide 3-kinase (PI3K)/Akt-dependent manner, resulting in ERG enrichment at Dll4 promoter and multiple enhancers. Finally, we demonstrate that ERG directly interacts with Notch intracellular domain (NICD) and ?-catenin and is required for Ang1-dependent ?-catenin recruitment at the Dll4 locus. We propose that ERG coordinates Ang1, ?-catenin and Notch signalling to promote vascular stability. |*Vascular Remodeling [MESH] |Adaptor Proteins, Signal Transducing [MESH] |Angiopoietin-1/*metabolism [MESH] |Animals [MESH] |Calcium-Binding Proteins [MESH] |Female [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/metabolism [MESH] |Jagged-1 Protein/metabolism [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Receptors, Notch/*metabolism [MESH] |Transcriptional Regulator ERG/metabolism [MESH]The endothelial transcription factor ERG mediates Angiopoietin-1-depen(epmc).pdf DeepDyve Pubget Overpricing