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2017 ; 11
(ä): 306
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Probabilistic White Matter Atlases of Human Auditory, Basal Ganglia, Language,
Precuneus, Sensorimotor, Visual and Visuospatial Networks
#MMPMID28751859
Figley TD
; Mortazavi Moghadam B
; Bhullar N
; Kornelsen J
; Courtney SM
; Figley CR
Front Hum Neurosci
2017[]; 11
(ä): 306
PMID28751859
show ga
Background: Despite the popularity of functional connectivity analyses and the
well-known topology of several intrinsic cortical networks, relatively little is
known about the white matter regions (i.e., structural connectivity) underlying
these networks. In the current study, we have therefore performed fMRI-guided
diffusion tensor imaging (DTI) tractography to create probabilistic white matter
atlases for eight previously identified functional brain networks, including the
Auditory, Basal Ganglia, Language, Precuneus, Sensorimotor, Primary Visual,
Higher Visual and Visuospatial Networks. Methods: Whole-brain diffusion imaging
data were acquired from a cohort of 32 healthy volunteers, and were warped to the
ICBM template using a two-stage, high-dimensional, non-linear spatial
normalization procedure. Deterministic tractography, with fractional anisotropy
(FA) ?0.15 and deviation angle <50°, was then performed using the Fiber
Association by Continuous Tracking (FACT) algorithm, and a multi-ROI approach to
identify tracts of interest. Regions-of-interest (ROIs) for each of the eight
networks were taken from a pre-existing atlas of functionally defined regions to
explore all ROI-to-ROI connections within each network, and all resulting
streamlines were saved as binary masks to create probabilistic atlases (across
participants) for tracts between each ROI-to-ROI pair. Results: The resulting
functionally-defined white matter atlases (i.e., for each tract and each network
as a whole) were saved as NIFTI images in stereotaxic ICBM coordinates, and have
been added to the UManitoba-JHU Functionally-Defined Human White Matter Atlas
(http://www.nitrc.org/projects/uofm_jhu_atlas/). Conclusion: To the best of our
knowledge, this work represents the first attempt to comprehensively identify and
map white matter connectomes for the Auditory, Basal Ganglia, Language,
Precuneus, Sensorimotor, Primary Visual, Higher Visual and Visuospatial Networks.
Therefore, the resulting probabilistic atlases represent a unique tool for future
neuroimaging studies wishing to ascribe voxel-wise or ROI-based changes (i.e., in
DTI or other quantitative white matter imaging signals) to these functional brain
networks.